Vimpat (lacosamide Tablet and Injection) Drug Information: Overdosage and Contraindications

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May 27, 2012

Vimpat

Seizures Symptoms and Types »

Generalized seizures

There are six types of generalized seizures. The most common and dramatic, and therefore the most well known, is the generalized convulsion, also called the grand-mal seizure. In this type of seizure, the patient loses consciousness and usually collapses. The loss of consciousness is followed by generalized body stiffening (called the "tonic" phase of the seizure) for 30 to 60 seconds, then by violent jerking (the "clonic" phase) for 30 to 60 seconds, after which the patient goes into a deep sleep (the "postictal" or after-seizure phase). During grand-mal seizures, injuries and accidents may occur, such as tongue biting and urinary incontinence.

Absence seizures cause a short loss of consciousness (just a few seconds) with few or no symptoms. The patient, most often a child, typically interrupts an activity and stares blankly. These seizures begin and end abruptly and may occur several times a day. Patients are usu...

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OVERDOSE

Signs, Symptoms, and Laboratory Findings of Acute Overdose in Humans

There is limited clinical experience with VIMPAT (lacosamide tablet and injection) overdose in humans. The highest reported accidental overdose of VIMPAT (lacosamide tablet and injection) during clinical development was 1200 mg/day which was non-fatal. The types of adverse events experienced by patients exposed to supratherapeutic doses during the trials were not clinically different from those of patients administered recommended doses of VIMPAT (lacosamide tablet and injection) .

There has been a single case of intentional overdose by a patient who self-administered 12 grams VIMPAT (lacosamide tablet and injection) along with large doses of zonisamide, topiramate, and gabapentin. The patient presented in a coma and was hospitalized. An EEG revealed epileptic waveforms. The patient recovered 2 days later.

Treatment or Management of Overdose

There is no specific antidote for overdose with VIMPAT (lacosamide tablet and injection) . Standard decontamination procedures should be followed. General supportive care of the patient is indicated including monitoring of vital signs and observation of the clinical status of patient. A Certified Poison Control Center should be contacted for up to date information on the management of overdose with VIMPAT (lacosamide tablet and injection) .

Standard hemodialysis procedures result in significant clearance of VIMPAT (lacosamide tablet and injection) (reduction of systemic exposure by 50% in 4 hours). Hemodialysis has not been performed in the few known cases of overdose, but may be indicated based on the patient's clinical state or in patients with significant renal impairment.