April 23, 2017
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Vincasar PFS

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Vincasar PFS

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

VINCASAR PFS®
(vincristine sulfate) injection USP




WARNING

Caution - This preparation should be administered by individuals experienced in the administration of VINCASAR PFS. It is extremely important that the intravenous needle or catheter be properly positioned before any vincristine is injected. Leakage into surrounding tissue during intravenous administration of VINCASAR PFS may cause considerable irritation. If extravasation occurs, the injection should be discontinued immediately, and any remaining portion of the dose should then be introduced into another vein. Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and are thought to minimize discomfort and the possibility of cellulitis.

FOR INTRAVENOUS USE ONLY - FATAL IF GIVEN BY OTHER ROUTES.

See OVERDOSAGE section for the treatment of patients given intrathecal VINCASAR PFS.

DRUG DESCRIPTION

VINCASAR PFS (vincristine sulfate injection USP) is vincaleukoblastine, 22-oxo-, sulfate (1:1) (salt). It is the salt of an alkaloid obtained from a common flowering herb, the periwinkle plant (Vinca rosea Linn). Originally known as leurocristine, it has also been referred to as LCR and VCR. The structural formula is as follows:

VINCASAR PFS® (vinCRIStine sulfate injection USP) Structural Formula Illustration

C46H56N4O10•H2SO4     M.W. 923.04

Vincristine Sulfate, USP is a white to slightly yellow powder. It is soluble in methanol, freely soluble in water, but only slightly soluble in 95% ethanol. In 98% ethanol, vincristine sulfate, USP has an ultraviolet spectrum with maxima at 221 nm (+47,100).

VINCASAR PFS (vincristine sulfate injection USP) is a sterile, preservative-free, single use only solution available for intravenous use in 1 mg (1 mg/1 mL) and 2 mg (2 mg/2 mL) vials. Each mL contains vincristine sulfate, USP, 1 mg (1.08 μmol); mannitol, 100 mg; and water for injection USP, qs. Acetic acid and sodium acetate have been added for pH control. The pH of VINCASAR PFS ranges from 3.5 to 5.5. This product is a sterile solution for cancer/oncolytic use.

What are the possible side effects of vincristine (Oncovin, Vincasar PFS)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • signs of infection such as fever, chills, sore throat, mouth pain, white patches or sores inside your mouth or on your lips;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots...

Read All Potential Side Effects and See Pictures of Vincasar PFS »

What are the precautions when taking vincristine sulfate injection (Vincasar PFS)?

Before using vincristine, tell your doctor or pharmacist if you are allergic to it or to vincristine liposomal; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: nerve/muscle problems (such as numbness/tingling/pain due to neuropathy, demyelinating conditions including Charcot-Marie-Tooth syndrome), liver disease, radiation treatment to the liver, decreased bone marrow function, blood disorders, current infection.

This medication can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to...

Read All Potential Precautions of Vincasar PFS »

Last reviewed on RxList: 8/29/2016
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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