Vioxx (Rofecoxib) Drug Information: Overdosage and Contraindications

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May 27, 2012

Vioxx

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Osteoarthritis is a joint inflammation that results from cartilage degeneration.
Osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
The most common symptom of osteoarthritis is pain in the affected joint(s) after repetitive use.
There is no blood test for the diagnosis of osteoarthritis.
The goal of treatment in osteoarthritis is to reduce joint pain and inflammation while improving and maintaining joint function.

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Osteoarthritis is a form of arthritis that features the breakdown and eventual loss of the cartilage of one or more joints. Cartilage is a protein substance that serves as a "cushion" between the bones of the joints. Among the over 100 different types of arthritis conditions, osteoarthritis is the most common, affecting over 25 million people in the United Stat...

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Vioxx

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

OVERDOSE

No overdoses of VIOXX (rofecoxib) were reported during clinical trials. Administration of single doses of VIOXX (rofecoxib) 1000 mg to 6 healthy volunteers and multiple doses of 250 mg/day for 14 days to 75 healthy volunteers did not result in serious toxicity.

In the event of overdose, it is reasonable to employ the usual supportive measures, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute supportive therapy, if required.

Rofecoxib is not removed by hemodialysis; it is not known whether rofecoxib is removed by peritoneal dialysis.

CONTRAINDICATIONS

VIOXX (rofecoxib) is contraindicated in patients with known hypersensitivity to rofecoxib or any other component of VIOXX (rofecoxib) .

VIOXX (rofecoxib) should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients (see WARNINGS, Anaphylactoid Reactions and PRECAUTIONS, Preexisting Asthma).

Last reviewed on RxList: 12/28/2004
This monograph has been modified to include the generic and brand name in many instances.