"What are COX-2 inhibitors, and how do they work?
COX-2 inhibitors are a subclass of nonsteroidal antiinflammatory drugs (NSAIDs). NSAIDs work by reducing the production of prostaglandins, chemicals that promote inflammation, pain, a"...
(Generic versions may still be available.)
- Clinician Information:
Vioxx Patient Information including If I Miss a Dose
In this Article
- What is rofecoxib (Vioxx)?
- What are the possible side effects of rofecoxib (Vioxx)?
- What is the most important information I should know about rofecoxib (Vioxx)?
- What should I discuss with my healthcare provider before taking rofecoxib (Vioxx)?
- How should I take rofecoxib (Vioxx)?
- What happens if I miss a dose (Vioxx)?
- What happens if I overdose (Vioxx)?
- What should I avoid while taking rofecoxib (Vioxx)?
- What other drugs will affect rofecoxib (Vioxx)?
- Where can I get more information?
What happens if I miss a dose (Vioxx)?
Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose as directed. Do not take a double dose of this medication unless your doctor directs otherwise.
What happens if I overdose (Vioxx)?
Seek emergency medical attention.
Symptoms of a rofecoxib overdose are not known.
What should I avoid while taking rofecoxib (Vioxx)?
There are no restrictions on food, beverages, or activity during treatment with rofecoxib, unless otherwise directed by your doctor.
What other drugs will affect rofecoxib (Vioxx)?
Before taking rofecoxib, tell your doctor if you are taking any of the following drugs:
- aspirin or an aspirin-like medication such as salsalate (Disalcid), choline salicylate-magnesium salicylate (Trilisate, Tricosal, others), and magnesium salicylate (Doan's, Bayer Select Backache Formula, others);
- an over-the-counter cough, cold, allergy, or pain medicine that contains aspirin, ibuprofen, naproxen, or ketoprofen;
- a diuretic (water pill) such as furosemide (Lasix), hydrochlorothiazide (Hydrodiuril, others), chlorothiazide (Diuril, others), chlorthalidone (Hygroton, Thalitone), and others;
- an angiotensin-converting-enzyme inhibitor (ACE inhibitor) such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), quinapril (Accupril), and others;
- a steroid medicine such as prednisone (Deltasone and others), methylprednisolone (Medrol and others), prednisolone (Prelone, Pediapred, and others), and others;
- an anticoagulant (blood thinner) such as warfarin (Coumadin);
- methotrexate (Rheumatrex, Folex);
- theophylline (Theo-Dur, Theobid, and others);
- lithium (Eskalith, Lithobid, others); or
- rifampin (Rimactane, Rifadin, Rifater).
You may not be able to take an rofecoxib, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
Drugs other than those listed here may also interact with rofecoxib. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.
Where can I get more information?
Your pharmacist has additional information about rofecoxib written for health professionals that you may read.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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Additional Vioxx Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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