DOSAGE AND ADMINISTRATION
Instill one drop of VIROPTIC (trifluridine) Ophthalmic Solution, 1% onto the cornea of the affected eye every 2 hours while awake for a maximum daily dosage of nine drops until the corneal ulcer has completely re-epithelialized. Following re-epithelialization, treatment for an additional 7 days of one drop every 4 hours while awake for a minimum daily dosage of five drops is recommended. If there are no signs of improvement after 7 days of therapy or complete re-epithelialization has not occurred after 14 days of therapy, other forms of therapy should be considered. Continuous administration of VIROPTIC (trifluridine) for periods exceeding 21 days should be avoided because of potential ocular toxicity.
VIROPTIC (trifluridine) Ophthalmic Solution, 1% is supplied as a sterile ophthalmic solution in a plastic Drop Dose® dispenser bottle of 7.5 mL (NDC 61570-037-75).
Store under refrigeration 2° to 8°C (36° to 46°F).
Prescribing Information as of April 2007. Distributed by: Monarch Pharmaceuticals, Inc., Bristol, TN 37620. Manufactured by: DSM Pharmaceuticals, Inc., Greenville, NC 27834This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 4/13/2009
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