"The U.S. Food and Drug Administration today notified Ranbaxy Laboratories, Ltd., that it is prohibited from manufacturing and distributing active pharmaceutical ingredients (APIs) from its facility in Toansa, India, for FDA-regulated drug product"...
No specific information on emergency treatment of overdosage is available. Therefore, on the basis of the pharmacologic actions of Visken ® (pindolol), the following general measures should be employed as appropriate in addition to gastric lavage:
Excessive Bradycardia : administer atropine; if there is no response to vagal blockade, administer isoproterenol cautiously.
Cardiac Failure : digitalize the patient and/or administer diuretic. It has been reported that glucagon may be useful in this situation.
Bronchospasm : administer a beta 2 stimulating agent such as isoproterenol and/or a theophylline derivative.
A case of an acute overdosage has been reported with an intake of 500 mg of Visken ® (pindolol) by a hypertensive patient. Blood pressure increased and heart rate was ³80 beats/min. Recovery was uneventful. In another case, 250 mg of Visken® (pindolol) was taken with 150 mg diazepam and 50 mg nitrazepam, producing coma and hypotension. The patient recovered in 24 hours.
Last reviewed on RxList: 2/13/2008
This monograph has been modified to include the generic and brand name in many instances.
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