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No specific information on emergency treatment of overdosage is available. Therefore, on the basis of the pharmacologic actions of Visken ® (pindolol), the following general measures should be employed as appropriate in addition to gastric lavage:
Excessive Bradycardia : administer atropine; if there is no response to vagal blockade, administer isoproterenol cautiously.
Cardiac Failure : digitalize the patient and/or administer diuretic. It has been reported that glucagon may be useful in this situation.
Bronchospasm : administer a beta 2 stimulating agent such as isoproterenol and/or a theophylline derivative.
A case of an acute overdosage has been reported with an intake of 500 mg of Visken ® (pindolol) by a hypertensive patient. Blood pressure increased and heart rate was ³80 beats/min. Recovery was uneventful. In another case, 250 mg of Visken® (pindolol) was taken with 150 mg diazepam and 50 mg nitrazepam, producing coma and hypotension. The patient recovered in 24 hours.
Last reviewed on RxList: 2/13/2008
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