Vitamin K1 (Aqueous Colloidal Solution of Vitamin K1) Patient Information: Side Effects and Drug Images at RxList

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May 27, 2012

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Celiac Disease »

Celiac disease facts

Celiac disease is a chronic digestive disorder in which damage to the lining of the small intestine leads to the malabsorption of minerals and nutrients.
The destruction of the inner lining of the small intestine in celiac disease is caused by an immunological (allergic) reaction to gluten.
Gluten is a family of proteins present in wheat, barley, rye, and sometimes oats.
Individuals with celiac disease may develop diarrhea, steatorrhea, weight loss, flatulence, iron deficiency anemia, abnormal bleeding, or weakened bones. However, many adults with celiac disease may have either no symptoms or only vague abdominal discomfort such as bloating, abdominal distension, and excess gas.
Children with celiac disease may have stunted growth, and if untreated, childhood celiac disease can result in short stature as an adult.
...

Read the Celiac Disease article »

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Vitamin K1

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Vitamin K1 Injection
(phytonadione) Injectable Emulsion, USP

Aqueous Dispersion of Vitamin K₁ Ampul

Protect from light. Keep ampuls in tray until time of use.

WARNING — INTRAVENOUS AND INTRAMUSCULAR USE

Severe reactions, including fatalities, have occurred during and immediately after INTRAVENOUS injection of phytonadione, even when precautions have been taken to dilute the phytonadione and to avoid rapid infusion. Severe reactions, including fatalities, have also been reported following INTRAMUSCULAR administration. Typically these severe reactions have resembled hypersensitivity or anaphylaxis, including shock and cardiac and/or respiratory arrest. Some patients have exhibited these severe reactions on receiving phytonadione for the first time. Therefore the INTRAVENOUS and INTRAMUSCULAR routes should be restricted to those situations where the subcutaneous route is not feasible and the serious risk involved is considered justified.

DRUG DESCRIPTION

Phytonadione is a vitamin, which is a clear, yellow to amber, viscous, odorless or nearly odorless liquid. It is insoluble in water, soluble in chloroform and slightly soluble in ethanol. It has a molecular weight of 450.70.

Phytonadione is 2-methyl-3-phytyl-1, 4-naphthoquinone. Its empirical formula is C₃₁H₄₆O₂ and its structural formula is:

VITAMIN K1 INJECTION (Phytonadione) Structural Formula Illustration

Vitamin K₁ Injection (Phytonadione Injectable Emulsion, USP) is a yellow, sterile, nonpyrogenic aqueous dispersion available for injection by the intravenous, intramuscular and subcutaneous routes. Each milliliter contains phytonadione 2 or 10 mg, polyoxyethylated fatty acid derivative 70 mg, dextrose, hydrous 37.5 mg in water for injection; benzyl alcohol 9 mg added as preservative. May contain hydrochloric acid for pH adjustment. pH is 6.3 (5.0 to 7.0). Phytonadione is oxygen sensitive.

Last reviewed on RxList: 11/7/2008
This monograph has been modified to include the generic and brand name in many instances.