Vitamin K1 (Aqueous Colloidal Solution of Vitamin K1) Drug Information: Side Effects and Drug Interactions

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May 27, 2012

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Celiac Disease »

Celiac disease facts

Celiac disease is a chronic digestive disorder in which damage to the lining of the small intestine leads to the malabsorption of minerals and nutrients.
The destruction of the inner lining of the small intestine in celiac disease is caused by an immunological (allergic) reaction to gluten.
Gluten is a family of proteins present in wheat, barley, rye, and sometimes oats.
Individuals with celiac disease may develop diarrhea, steatorrhea, weight loss, flatulence, iron deficiency anemia, abnormal bleeding, or weakened bones. However, many adults with celiac disease may have either no symptoms or only vague abdominal discomfort such as bloating, abdominal distension, and excess gas.
Children with celiac disease may have stunted growth, and if untreated, childhood celiac disease can result in short stature as an adult.
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Read the Celiac Disease article »

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SIDE EFFECTS

Deaths have occurred after intravenous and intramuscular administration. (See Box Warning.)

Transient "flushing sensations" and "peculiar" sensations of taste have been observed, as well as rare instances of dizziness, rapid and weak pulse, profuse sweating, brief hypotension, dyspnea, and cyanosis.

Pain, swelling, and tenderness at the injection site may occur.

The possibility of allergic sensitivity including an anaphylactoid reaction, should be kept in mind.

Infrequently, usually after repeated injection, erythematous, indurated, pruritic plaques have occurred; rarely, these have progressed to scleroderma-like lesions that have persisted for long periods. In other cases, these lesions have resembled erythema perstans.

Hyperbilirubinemia has been observed in the newborn following administration of phytonadione. This has occurred rarely and primarily with doses above those recommended. (See PRECAUTIONS, Pediatric Use.)

DRUG INTERACTIONS

Temporary resistance to prothrombin-depressing anticoagulants may result, especially when larger doses of phytonadione are used. If relatively large doses have been employed, it may be necessary when reinstituting anticoagulant therapy to use somewhat larger doses of the prothrombin- depressing anticoagulant, or to use one which acts on a different principle, such as heparin sodium.

Last reviewed on RxList: 11/7/2008
This monograph has been modified to include the generic and brand name in many instances.