June 26, 2016

Vitamin D

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What other names is Vitamin D known by?

Alfacalcidol: 1-alpha-hydroxycholecalciferol, 1-alpha-hydroxycholécalciférol, 1 alpha (OH)D3.
Calcifediol: 25-HCC, 25-hydroxycholecalciferol, 25-hydroxycholécalciferol , 25-hydroxyvitamin D3, 25-hydroxyvitamine D3, 25-OHCC, 25-OHD3, Calcifédiol.
Calcipotriene : Calcipotriène, Calcipotriol.
Calcitriol: 1,25-DHCC, 1,25-dihydroxycholecalciferol, 1,25-dihydroxycholécalciférol, 1,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamine D3, 1,25-diOHC, 1,25(0H)2D3.
Cholecalciferol: 7-déhydrocholestérol Activé, Activated 7-dehydrocholesterol, Cholécalciférol, Colecalciferol, Colécalciférol, Vitamin D3.
Dihydrotachysterol: DHT, Dihydrotachystérol, dihydrotachysterol 2, dichysterol, Vitamine D3.
Ergocalciferol: Activated Ergosterol, Calciferol, Ergocalciférol, Ergocalciferolum, Ergostérol Activé, Ergostérol Irradié, Irradiated Ergosterol, Viosterol, Viostérol, Vitamin D2, Vitamine D2.
Paricalcitol: 19-nor-1,25-dihydroxyvitamin D2, 19-nor-1,25-dihydroxyvitamine D2, Paracalcin.
Fat-Soluble Vitamin, Vitamina D, Vitamine D, Vitamine Liposoluble, Vitamine Soluble dans les Graisses.

What is Vitamin D?

Vitamin D is a vitamin. It can be found in small amounts in a few foods, including fatty fish such as herring, mackerel, sardines and tuna. To make vitamin D more available, it is added to dairy products, juices, and cereals that are then said to be "fortified with vitamin D." But most vitamin D - 80% to 90% of what the body gets - is obtained through exposure to sunlight. Vitamin D can also be made in the laboratory as medicine.

Vitamin D is used for preventing and treating rickets, a disease that is caused by not having enough vitamin D (vitamin D deficiency). Vitamin D is also used for treating weak bones (osteoporosis), bone pain (osteomalacia), bone loss in people with a condition called hyperparathyroidism, and an inherited disease (osteogenesis imperfecta) in which the bones are especially brittle and easily broken. It is also used for preventing falls and fractures in people at risk for osteoporosis, and preventing low calcium and bone loss (renal osteodystrophy) in people with kidney failure.

Vitamin D is used for conditions of the heart and blood vessels, including high blood pressure and high cholesterol. It is also used for diabetes, obesity, muscle weakness, multiple sclerosis, rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), asthma, bronchitis, premenstrual syndrome (PMS), and tooth and gum disease.

Some people use vitamin D for skin conditions including vitiligo, scleroderma, psoriasis, actinic keratosis, and lupus vulgaris.

It is also used for boosting the immune system, preventing autoimmune diseases, and preventing cancer.

Because vitamin D is involved in regulating the levels of minerals such as phosphorous and calcium, it is used for conditions caused by low levels of phosphorous (familial hypophosphatemia and Fanconi syndrome) and low levels of calcium (hypoparathyroidism and pseudohypoparathyroidism).

Vitamin D in forms known as calcitriol or calcipotriene is applied directly to the skin for a particular type of psoriasis.

If you travel to Canada, you may have noticed that Canada recognizes the importance of vitamin D in the prevention of osteoporosis. It allows this health claim for foods that contain calcium: "A healthy diet with adequate calcium and vitamin D, and regular physical activity, help to achieve strong bones and may reduce the risk of osteoporosis." But the US version of this osteoporosis health claim does not yet include vitamin D.

Effective for...

  • Low levels of phosphate in the blood due to an inherited disorder called familial hypophosphatemia. Taking vitamin D (calcitriol or dihydrotachysterol) by mouth along with phosphate supplements is effective for treating bone disorders in people with low levels of phosphate in the blood.
  • Low levels of phosphate in the blood due to a disease called Fanconi syndrome. Taking vitamin D (ergocalciferol) by mouth is effective for treating low levels of phosphate in the blood due to a disease called Fanconi syndrome.
  • Low blood calcium levels due to low parathyroid hormone levels. Low levels of parathyroid hormone can cause calcium levels to become too low. Taking vitamin D (dihydrotachysterol, calcitriol, or ergocalciferol) by mouth is effective for increasing calcium blood levels in people with low parathyroid hormone levels.
  • Softening of the bones (osteomalacia). Taking vitamin D (cholecalciferol) is effective for treating softening of the bones. Also, taking vitamin D (calcifediol) is effective for treating softening of the bones due to liver disease. In addition, taking vitamin D (ergocalciferol) is effective for treating softening of the bones caused by medications or poor absorption syndromes.
  • Psoriasis. Applying vitamin D or calcipotriene (a synthetic form of vitamin D) to the skin treats psoriasis in some people. Applying vitamin D to the skin together with cream containing drugs called corticosteroids seems to be more effective for treating psoriasis than using just vitamin D or the corticosteroid creams alone.
  • A bone disorder called renal osteodystrophy, which occurs in people with kidney failure. Taking vitamin D (calcifediol) by mouth manages low calcium levels and prevents bone loss in people with kidney failure. However, vitamin D does not appear to reduce the risk of death or bone pain in people with kidney failure.
  • Rickets. Vitamin D is effective for preventing and treating rickets. A specific form of vitamin D, calcitriol, should be used in people with kidney failure.
  • Vitamin D deficiency. Vitamin D is effective for preventing and treating vitamin D deficiency.

Likely Effective for...

  • Bone loss in people taking drugs called corticosteroids. Taking vitamin D (calcifediol, cholecalciferol, calcitriol, or alfacalcidol) by mouth prevents bone loss in people taking drugs called corticosteroids. Taking vitamin D alone or with calcium seems to improve bone density in people with existing bone loss caused by using corticosteroids.
  • Preventing falls in older people. Researchers have observed that people who do not have enough vitamin D tend to fall more often than people who do. Taking a vitamin D supplement seems to reduce the risk of falling by up to 22%. Higher doses of vitamin D are more effective than lower doses. One study found that taking 800 IU of vitamin D reduced the risk of falling, but lower doses did not.
  • Also, vitamin D, in combination with calcium, but not calcium alone, may prevent falls by decreasing body sway and blood pressure. Taking vitamin D plus calcium seems to prevent falls more significantly in women than men and in older people living in hospitals or residential care facilities than those living in community dwellings.
  • Osteoporosis (weak bones). Taking a specific form of vitamin D called cholecalciferol (vitamin D3) along with calcium seems to help prevent bone loss and bone breaks.

Possibly Effective for...

  • Cancer. Some research shows that people who take a high-dose vitamin D supplement plus calcium might have a lower risk of developing certain types of cancer. However, taking vitamin D alone does not appear to reduce the risk of cancer.
  • Cavities. Research suggests that taking vitamin D3 (cholecalciferol) reduces the risk of cavities by 49% and vitamin D2 (ergocalciferol) reduces the risk by 36% in infants, children and adolescents.
  • Bone loss caused by having too much parathyroid hormone (hyperparathyroidism). Taking vitamin D (cholecalciferol) by mouth seems to reduce parathyroid hormone levels and bone loss in women with a condition called hyperparathyroidism.
  • Multiple sclerosis (MS). Research shows that taking vitamin D can reduce the risk of developing MS in women by up to 40%. Taking at least 400 IU daily, the amount typically found in a multivitamin supplement, seems to work the best.
  • Respiratory infections. Research in school aged children shows that taking a vitamin D supplement during winter might reduce the chance of developing seasonal flu. Other research suggests that taking a vitamin D supplement might reduce the chance of an asthma attack triggered by a cold or other respiratory infection. Some additional research suggests that children with low levels of vitamin D have a higher chance of developing a respiratory infection such as the common cold or flu. However, most research suggests that vitamin D might only have an effect on respiratory infections in children. It does not appear to provide the same benefits in adults.
  • Rheumatoid arthritis. Research suggests that older women who consume more vitamin D from foods or supplements tend to have a lower risk of developing rheumatoid arthritis.
  • Tooth loss. Taking calcium and vitamin D by mouth appears to prevent tooth loss in elderly people.
  • Weight loss. Research shows that people with lower vitamin D levels are more likely to be obese than those with higher levels. Women taking calcium plus vitamin D are more likely to lose weight and maintain their weight. However, this benefit is mainly in women who did not consume enough calcium before they started taking supplements.

Possibly Ineffective for...

  • Breast cancer. Evidence on the effects of vitamin D on breast cancer risk is inconsistent. The best evidence comes from a large study called the Women's Health Initiative, which found that taking 400 IU of vitamin D and 1000 mg of calcium per day does not lower the chance of getting breast cancer when taken by postmenopausal women. However, the possibility remains that high doses of vitamin D might lower breast cancer risk in younger women.
  • Muscle strength. Taking vitamin D (cholecalciferol) by mouth daily does not increase muscle strength or improve physicical performance in healthy older men who are not vitamin D deficient.
  • Bone loss in people with kidney transplants. Taking vitamin D (calcitriol) daily together with calcium carbonate does not decrease bone loss in people with kidney transplants.
  • Tuberculosis. Vitamin D does not appear to help cure tuberculosis infections.

Insufficient Evidence to Rate Effectiveness for...

  • Asthma. Some research suggests that people with asthma are more likely to have low vitamin D levels. In children with asthma, taking a vitamin D supplement might reduce the chance of an asthma attack during a cold or other respiratory infection. However, it is too soon to know if taking a vitamin D supplement can prevent or treat asthma symptoms.
  • Heart disease. Research suggests that people with low levels of vitamin D in their blood are more likely to develop heart disease, including heart failure, than people with higher vitamin D levels. However, taking vitamin D does not seem to extend the life of people with heart failure.
  • Kidney disease. Research suggests that vitamin D decreases parathyroid hormone levels in people with chronic kidney disease. However, taking vitamin D does not appear to lower the risk of death in people with kidney disease.
  • Chronic obstructive pulmonary disease (COPD). Some research shows that people with COPD have lower than normal vitamin D levels. However, there is not enough information to know if taking a vitamin D supplement can decrease symptoms of COPD.
  • Mental function. Research shows that vitamin D levels are not linked to improved or worsened mental function.
  • Colorectal cancer. It is not clear if vitamin D might benefit colorectal cancer. Some research shows that calcium intake is linked with a reduced risk of developing colorectal cancer. However, this effect is not seen in people with low vitamin D levels, indicating that vitamin D might be an important factor. However, other research suggests that taking vitamin D with calcium is not associated with a lower risk of colorectal cancer.
  • Diabetes. Research shows that people with lower vitamin D levels are more likely to develop type 2 diabetes compared to people with higher vitamin D levels. However, there is no reliable evidence that taking vitamin D supplements can treat or prevent type 2 diabetes. Early evidence suggests that giving vitamin D supplements to infants daily during the first year of life is linked to a lower risk of developing type 1 diabetes later in life.
  • Heart failure. Some research suggests that people with low vitamin D levels have an increased risk of developing heart failure compared to those with higher vitamin D levels. However, other research shows that taking vitamin D (cholecalciferol) daily does not decrease the risk of death in people with heart failure.
  • High cholesterol. People with lower vitamin D levels seem to be much more likely to have high cholesterol than people with higher vitamin D levels. Limited research shows that taking calcium plus vitamin D daily, in combination with a low-calorie diet, significantly raises "good (HDL) cholesterol" and lowers "bad (LDL) cholesterol" in overweight women. However, taking calcium plus vitamin D without dietary restrictions does not reduce LDL cholesterol levels. Other research suggests that vitamin D might actually increase LDL and have no beneficial effect on HDL, triglycerides, or total cholesterol.
  • High blood pressure. Research suggests that lower vitamin D levels are associated with a higher risk of developing high blood pressure. However, research is inconsistent. Some research suggests that vitamin D can reduce blood pressure in people with or without high blood pressure. Other research shows that taking vitamin D (cholecalciferol) daily in combination with calcium does not lower blood pressure or reduce the risk of developing high blood pressure in postmenopausal women.
  • Low birth weight. Research suggests that mothers who take vitamin D supplements during pregnancy have a lower risk of delivering a low birth weight infant.
  • Metabolic syndrome. There is conflicting evidence about the link between vitamin D and metabolic syndrome. Some research suggests that women aged at least 45 years who consume high amounts of vitamin D or take vitamin D supplements do not have a lower risk of developing metabolic syndrome. However, other research suggests that higher vitamin D levels are linked to a lower risk of metabolic syndrome.
  • Overall death risk. Research suggests that having low vitamin D levels is associated with an increased risk of death from any cause. Some research suggests that people who take vitamin D supplements daily have a lower risk of dying. However, other research suggests that vitamin D reduces the risk of death only when taking together with calcium.
  • A blood cell disease called myelodysplastic syndrome. Taking vitamin D (calcitriol or calcifediol) by mouth seems to help people with myelodysplastic syndrome.
  • Gum disease. Research shows that higher blood levels of vitamin D seem to be linked with a reduced risk of gum disease in people 50 years of age or older. However, this does not seem to be true for adults younger than 50 years.
  • Premenstrual syndrome (PMS). There is some evidence that consuming more vitamin D from the diet might help to prevent PMS or reduce symptoms. Taking vitamin D supplements does not seem to prevent PMS. However taking vitamin D plus calcium seems to reduce PMS symptoms.
  • A muscle disease called proximal myopathy. Taking vitamin D (ergocalciferol) by mouth or administering it as a shot into the muscle seems to help treat a muscle disease associated with vitamin D deficiency.
  • Seasonal depression (seasonal affective disorder). Early research suggests that vitamin D improves symptoms of seasonal depression.
  • Non-cancerous wart-like growths on the skin (seborrheic keratosis). Early research suggests that applying vitamin D3 (cholecalciferol) to the skin might reduce tumor size in some people with seborrheic keratosis.
  • Muscle pain caused by medications called statins. Some reports suggest that taking vitamin D supplements can decrease symptoms of muscle pain in people taking statin drugs.
  • Vaginal atrophy. Early research shows that taking vitamin D supplements for a least one year improves the surface of the vaginal wall. However, it does not seem to improve symptoms of vaginal atrophy.
  • Warts. Reports suggest that applying maxacalcitol, which comes from vitamin D3, to the skin, can reduce viral warts in people with weakened immune systems.
  • Bronchitis.
  • Breathing disorders.
  • Other conditions.
More evidence is needed to rate vitamin D for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).


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