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Vitravene

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Vitravene

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

VITRAVENE (fomivirsen) TM Injection
Fomivirsen sodium intravitreal injectable

DRUG DESCRIPTION

Vitravene† (fomivirsen sodium intravitreal injectable) is a sterile, aqueous, preservative-free, bicarbonate-buffered solution for intravitreal injection. Fomivirsen sodium is represented by the following structual formula:

 

Fomivirsen sodium is a phosphorothioate oligonucleotide, twenty-one nucleotides in length, with the following sequence: 5'-GCG TTT GCT CTT CTT CTT GCG-3'

The chemical name for fomivirsen sodium is as follows:

2'-Deoxyguanosylyl-(3'->5' O,O -phosphorothioyl)-2'-deoxycytidylyl-(3'->5' O,O -phosphorothioyl)-2'-deoxyguanosylyl-(3'->5' O,O -phosphorothioyl)-thymidylyl-(3'->5' O,O -phosphorothioyl)-thymidylyl-(3'->5' O,O -phos-phorothioyl)-thymidylyl-(3'->5' O,O -phosphorothioyl)-2'-deoxyguanosylyl-(3'->5' O,O -pho-sphorothioyl)-2'-deoxycytidylyl-(3'->5' O,O -phosphorothioyl)-thymidylyl-(3'->5' O,O -pho-sphorothioyl)-2'-deoxycytidylyl-(3'->5' O,O -phosphorothioyl)-thymidylyl-(3'->5' O,O -pho-sphorothioyl)-thymidylyl-(3'->5' O,O -phosphorothioyl)-2'-deoxycytidylyl-(3'->5' O,O -phosphorothioyl)-thymidylyl-(3'->5' O,O -pho-sphorothioyl)-thymidylyl-(3'->5' O,O -phosphorothioyl)-2'-deoxycytidylyl-(3'->5' O,O -phosphorothioyl)-thymidylyl-(3'->5' O,O -pho-sphorothioyl)-thymidylyl-(3'->5' O,O -phosphorothioyl)-2'-deoxyguanosylyl-(3'->5' O,O -phosphorothioyl)-2'-deoxycytidylyl-(3'->5' O,O -phosphorothioyl)-2'-deoxyguanosine, 20-sodium salt.

Fomivirsen sodium is a white to off-white, hygroscopic, amorphous powder with a molecular formula of C 204 H 243 N 63 O 114 P 20 S 20 Na 20 and a molecular weight of 7,122.

Each mL of Vitravene (fomivirsen) † contains:

ACTIVE:   Fomivirsen sodium 6.6 mg

INACTIVES:   Sodium chloride, sodium bicarbonate, sodium carbonate and water for injection. Sodium hydroxide and/or hydrochloric acid may be added to adjust pH. Vitravene (fomivirsen) † is formulated to have an osmolality of 290 mOsm/kg, and a pH of 8.7.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

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