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Vivotif Oral

Vivotif Oral


Clinical Trials

The following adverse effects were reported as common (in accordance with CIOMS definition of <1/10 and >1/100) and were generally mild - constipation, abdominal cramps, diarrhoea, nausea, vomiting, anorexia, fever, headache and urticarial exanthema.

Postmarketing Data

The following additional adverse effects have been reported very rarely (CIOMS definition: <1/10,000) during postmarketing surveillance.

Skin reactions such as dermatitis, exanthema, pruritus and urticaria, anaphylaxis, asthenia, malaise, tiredness, shivering, paraesthesia, dizziness, arthralgia and myalgia.

Read the Vivotif Oral (typhoid vaccine) Side Effects Center for a complete guide to possible side effects


Interactions with Other Medicines

The vaccine should not be administered concurrently with antibiotics or other drugs (eg. sulphonamides) that are active against salmonellae. The vaccine should be administered first and at least 3 days should elapse between the final dose of the vaccine and such drugs.

The simultaneous administration of Vivotif Oral Typhoid Vaccine and parenteral (live attenuated) yellow fever vaccine, or inactivated vaccines, or oral polio vaccines, or parenteral immunoglobulin preparations, has been reported not to interfere with the immune response. See also under "Anti-Malaria Prophylaxis" in "Interactions with Other Medicines".

Anti-Malaria Prophylaxis


In the case of planned anti-malarial prophylaxis, immunisation with Vivotif Oral Typhoid Vaccine should precede anti-malaria prophylaxis. The interval between the last dose of Vivotif Oral Typhoid Vaccine and the beginning of anti-malarial prophylaxis should, in general, be at least 3 days.

If anti-malaria prophylaxis has been started, the minimum interval between the last dose of anti-malaria prophylaxis and the first dose of Vivotif Oral Typhoid Vaccine should be at least 3 days.

This 3-day interval should generally be regarded as optimal.

Chloroquine and/or pyrimethamine/sulfadoxine

Vivotif Oral Typhoid Vaccine can be given with chloroquine and/or pyrimethamine/sulfadoxine. In these studies, the anti-malarials were given first, followed 12 hours later by Vivotif Oral (typhoid vaccine) Typhoid capsule.


Mefloquine can be given concomitantly with Vivotif Oral Typhoid Vaccine. A lower IgG response was observed compared to taking Vivotif Oral Typhoid Vaccine alone, however the immune response was not affected and vaccine efficacy was not compromised.

Atavoquone and proguanil, fixed combination

Atavaquone and proguanil (fixed combination formulation) may be given concomitantly with Vivotif Oral Typhoid Vaccine.


Proguanil, when given alone, should be administered only if 10 days or more have elapsed since the final dose of Vivotif Oral Typhoid Vaccine.

Last reviewed on RxList: 9/30/2008
This monograph has been modified to include the generic and brand name in many instances.


Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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