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Vivotif Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Vivotif Oral (typhoid vaccine) is a "live" immunization used to help prevent infection (typhoid fever) caused by the bacteria Salmonella typhi. Vivotif Oral is recommended for people older than 6 years who are traveling to areas where typhoid fever is common (i.e., Central and South America, Africa, Asia), who are exposed to someone with typhoid infection, or who work with the bacteria in a laboratory. Common side effects of Vivotif Oral include nausea, vomiting, diarrhea, stomach pain, fever, headache, or skin rash.
The complete immunization schedule for adults and children above 6 years of age is the ingestion of one Vivotif Oral capsule on each of days 1, 3 and 5. Before receiving Vivotif Oral vaccine, tell the doctor all other vaccines you have recently received. Vivotif Oral may interact with proguanil (Malarone). Other drugs may affect this vaccine. Tell your doctor all prescription and over-the-counter medications you use. During pregnancy, Vivotif Oral vaccine should be used only when prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.
Our Vivotif Oral (typhoid vaccine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Vivotif in Detail - Patient Information: Side Effects
You should not receive a booster dose if you had a life-threatening allergic reaction after taking a typhoid vaccine capsule.
Becoming infected with typhoid fever is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Less serious side effects include:
- low fever;
- nausea, vomiting, diarrhea, stomach pain; or
- mild skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.
Read the entire detailed patient monograph for Vivotif (Typhoid Vaccine)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Vivotif Overview - Patient Information: Side Effects
Remember that your health care professional has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Contact the doctor for medical advice about side effects. The following numbers do not provide medical advice, but in the US you may report side effects to the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967. In Canada, you may call the Vaccine Safety Section at Public Health Agency of Canada at 1-866-844-0018.
Read the entire patient information overview for Vivotif (Typhoid Vaccine)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Vivotif FDA Prescribing Information: Side Effects
More than 1.4 million doses of Ty21a have been administered in controlled clinical trials and more than 150 million doses of Vivotif (Typhoid Vaccine Live Oral Ty21a) have been marketed world-wide. Active surveillance for adverse reactions of enteric-coated capsules was performed in a pilot study21 and in a subgroup of a large field trial14 involving a total of 483 individuals receiving 3 vaccine doses. The overall symptom rates from both studies when vaccinated with capsules were combined and shown to be: abdominal pain (6.4%), nausea (5.8%), headache (4.8%), fever (3.3%), diarrhea (2.9%), vomiting (1.5%) and skin rash (1.0%). Only the incidence of nausea occurred at a statistically higher frequency in the vaccinated group as compared to the placebo group14. Administration of vaccine doses more than 5-fold higher than the currently recommended dose caused only mild reactions in an open study involving 155 healthy adult males16.
Post-marketing surveillance has revealed that adverse reactions are infrequent and mild17. Adverse reactions reported to the manufacturer during 1991-1995, during which time over 60 million doses (capsules) were administered, included: diarrhea (N = 45), abdominal pain (N = 42), nausea (N = 35), fever (N = 34), headache (N = 26), skin rash (N = 26), vomiting (N = 18), or urticaria in the trunk and/or extremities (N = 13). One isolated, non-fatal anaphylactic shock considered to be an allergic reaction to the vaccine was reported.
To report SUSPECTED ADVERSE REACTIONS, contact Crucell Vaccines, Inc. at 1-800- 533-5899 http://www.crucell.com.us; or contact the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967 or http://www.fda.gov/vaers
Read the entire FDA prescribing information for Vivotif (Typhoid Vaccine)
Additional Vivotif Oral Information
Vivotif Oral - User Reviews
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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