August 24, 2016
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Voluven

"For the first time, patients in the United States who develop the rare life-threatening complication of hepatic veno-occlusive disease (VOD) following a hematopoietic stem cell transplant (HSCT) have a treatment.

Defibrotide sodium ("...

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Voluven

Overdosage
Contraindications

OVERDOSE

Overdosage can lead to overloading of the circulatory system (e.g., pulmonary edema). In this case, the infusion should be stopped immediately and if necessary, a diuretic should be administered. [see General WARNINGS AND PRECAUTIONS]

CONTRAINDICATIONS

  • Do not use hydroxyethyl starch (HES) products, including Voluven®, in critically ill adult patients, including patients with sepsis, due to increased risk of mortality and renal replacement therapy.
  • Do not use HES products, including Voluven®, in patients with severe liver disease.
  • Do not use HES products, including Voluven®, in patients with known hypersensitivity to hydroxyethyl starch. [see General WARNINGS AND PRECAUTIONS]
  • Do not use HES products in clinical conditions with volume overload.
  • Do not use HES products in patients with pre-existing coagulation or bleeding disorders.
  • Do not use HES products in patients with renal failure with oliguria or anuria not related to hypovolemia.
  • Do not use HES products in patients receiving dialysis treatment.
  • Do not use HES products in patients with severe hypernatremia or severe hyperchloremia.
  • Do not use HES products in patients with intracranial bleeding.
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 7/13/2016

Overdosage
Contraindications

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