Votrient
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The kidneys are a pair of organs on either side of the spine in the lower abdomen. Each kidney is about the size of a fist. Attached to the top of each kidney is an adrenal gland. "...
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Votrient
VOTRIENT
(pazopanib)
WARNING
HEPATOTOXICITY
Severe and fatal hepatotoxicity has been observed in clinical studies. Monitor hepaticfunction and interrupt, reduce, or discontinue dosing as recommended. [See WARNINGS AND PRECAUTIONS.]
DRUG DESCRIPTION
VOTRIENT (pazopanib) is a tyrosine kinase inhibitor (TKI). Pazopanib is presented as the hydrochloride salt, with the chemical name 5-[[4-[(2,3-dimethyl-2H-indazol-6- yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide monohydrochloride. It has the molecular formula C21H23N7O2S•HCl and a molecular weight of 473.99. Pazopanib hydrochloride has the following chemical structure:
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Pazopanib hydrochloride is a white to slightly yellow solid. It is very slightly soluble at pH 1 and practically insoluble above pH 4 in aqueous media.
Tablets of VOTRIENT are for oral administration. Each 200 mg tablet of VOTRIENT contains 216.7 mg of pazopanib hydrochloride, equivalent to 200 mg of pazopanib free base.
The inactive ingredients of VOTRIENT are: Tablet Core: Magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate. Coating: Gray film-coat: Hypromellose, iron oxide black, macrogol/polyethylene glycol 400 (PEG 400), polysorbate 80, titanium dioxide.
What are the possible side effects of pazopanib (Votrient)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using pazopanib and call your doctor at once if you have a serious side effect such as:
- slow healing of a wound or surgical incision;
- dizziness, fainting, fast or pounding heartbeat;
- black, bloody, or tarry stools;
- coughing up blood or vomit that looks like coffee grounds;
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing...
Read All Potential Side Effects and See Pictures of Votrient »
What are the precautions when taking pazopanib tablets (Votrient)?
Before taking pazopanib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, chest pain/heart attack, high blood pressure, stroke, bleeding/clotting problem, intestinal or stomach problems (such as ulcer, fistula, pancreatitis), underactive thyroid.
Pazopanib may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that...
Last reviewed on RxList: 4/4/2012
This monograph has been modified to include the generic and brand name in many instances.
Additional Votrient Information
Votrient - User Reviews
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