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In this Article

• What is lisdexamfetamine (Vyvanse)?
• What are the possible side effects of lisdexamfetamine (Vyvanse)?
• What is the most important information I should know about lisdexamfetamine (Vyvanse)?
• What should I discuss with my doctor before taking lisdexamfetamine (Vyvanse)?
• How should I take lisdexamfetamine (Vyvanse)?
• What happens if I miss a dose (Vyvanse)?
• What happens if I overdose (Vyvanse)?
• What should I avoid while taking lisdexamfetamine (Vyvanse)?
• What other drugs will affect lisdexamfetamine (Vyvanse)?
• Where can I get more information?

What should I discuss with my doctor before taking lisdexamfetamine (Vyvanse)?

Do not use lisdexamfetamine if you have used an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take lisdexamfetamine before the MAO inhibitor has cleared from your body.

Do not use this medication if you are allergic to lisdexamfetamine or if you have:

• heart disease or moderate to severe high blood pressure (hypertension);
• arteriosclerosis (hardening of the arteries);
• overactive thyroid;
• glaucoma;
• severe anxiety, tension, or agitation; or
• if you have a history of drug or alcohol addiction.

Some stimulants have caused sudden death in children and adolescents with serious heart problems or congenital heart defects.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take lisdexamfetamine:

• a congenital heart defect;
• high blood pressure;
• heart failure, heart rhythm disorder, or recent heart attack;
• a personal or family history of mental illness, psychotic disorder, bipolar illness, depression, or suicide attempt;
• epilepsy or other seizure disorder; or
• tics (muscle twitches) or Tourette's syndrome.

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. However, it could cause premature birth, low birth weight, or withdrawal symptoms in a newborn if the mother takes lisdexamfetamine during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Lisdexamfetamine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Long-term use of lisdexamfetamine can slow a child's growth. Tell your doctor if the child using this medication is not growing or gaining weight properly.

Do not give this medication to a child younger than 6 years old without the advice of a doctor.

Lisdexamfetamine may be habit-forming and should be used only by the person it was prescribed for. Lisdexamfetamine should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Using this medication improperly can cause death or serious side effects on the heart.

How should I take lisdexamfetamine (Vyvanse)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication. You may also be asked to not use the medication for a day or two and watch for any differences in behavior off the medication.

Take this medication with a full glass of water.

It is best to take this medication in the morning. Do not take lisdexamfetamine in the afternoon or evening because it may cause sleep problems (insomnia).

You may take lisdexamfetamine with or without food.

The capsule should be swallowed whole. You may also open the lisdexamfetamine capsule and sprinkle the medicine into a glass of water. After the medicine has dissolved, drink this mixture right away. Do not save the mixture for later use. Discard the empty capsule.

To be sure this medication is helping your condition, your doctor will need to see you on a regular basis. Do not miss any scheduled appointments.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using lisdexamfetamine.

Store lisdexamfetamine at room temperature away from moisture, heat, and light.

Keep track of how many capsules have been used from each new bottle of this medicine. Lisdexamfetamine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.