November 26, 2015
font size

Wegener's Granulomatosis (cont.)

Medical Author:

What are symptoms of granulomatosis with polyangiitis (GPA)?

Symptoms of granulomatosis with polyangiitis (GPA) are:

  • bloody sputum,
  • fevers,
  • fatigue,
  • joint pains,
  • shortness of breath,
  • sinus inflammation (sinusitis), and
  • weight loss.

Nasal ulcerations and even bloody nasal discharge can occur. Other areas of the body that can also become inflamed in patients with GPA include the eyes, the nerves (neuropathy), the middle ear (otitis media), and the skin resulting in skin nodules or ulcers.

How is granulomatosis with polyangiitis (GPA) diagnosed?

Abnormal lab findings in patients with granulomatosis with polyangiitis (GPA) include urine tests that detect protein and red blood cells in the urine (not visible to the naked eye) and x-ray tests of the chest and sinuses which detect abnormalities resulting from lung and sinus inflammation. Blood tests that detect the abnormal inflammation include the sedimentation rate (sed rate) and C-reactive protein. A more specific blood test used to diagnose and monitor Wegener's granulomatosis is the antineutrophil cytoplasmic antibody (ANCA test), which is commonly elevated when the disease is active.

The diagnosis of GPA is confirmed by detecting both abnormal cellular formations, called granulomas, and vasculitis in a biopsy of tissue involved with the inflammatory process. For examples, an open lung biopsy or a kidney biopsy are commonly used in making a diagnosis of granulomatosis with polyangiitis.

Medically Reviewed by a Doctor on 5/20/2015



Get the latest treatment options

Wegener's Granulomatosis Related Articles
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations