Wheat Bran

Are there any interactions with medications?

---

Digoxin (Lanoxin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Wheat bran is high in fiber. Fiber can decrease the absorption and decrease the effectiveness of digoxin (Lanoxin). As a general rule, any medications taken by mouth should be taken one hour before or four hours after wheat bran to prevent this interaction.

Dosing considerations for Wheat Bran.

The following doses have been studied in scientific research:

BY MOUTH:

• For constipation: 20 to 25 grams of wheat bran per day. It appears that 40 grams per day is no more effective than 20 grams per day.
• For the treatment of irritable bowel syndrome (IBS): 30 grams of wheat bran per day for up to 12 weeks.
• For high blood pressure: 3-6 grams of whole-wheat flour, wheat flakes, and brown rice, combined with a National Cholesterol Education Program (NCEP) step 1 diet.

Adequate intake (AI) levels for dietary fiber intake per day have been set. For children 1 to 3 years, the AI is 19 grams; for children 4 to 8 years, 25 grams. For boys 9 to 13 years, the AI is 31 grams; for boys 14 to 18 years, 38 grams. For girls 9 to 18 years, the AI is 26 grams. For men 19 to 50 years, the AI is 38 grams, and 30 grams for men older than 51 years. For women 19 to 50 years, the AI is 25 grams, and 21 grams for women older than 51 years. For pregnant women, the AI is 28 grams, and 29 grams for breast-feeding women. AI for children less than one year has not been set.

A tolerable upper intake levels (UL) for fiber, the highest intake level at which no unwanted side effects are expected, has not been set.