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home > drugs a-z list > wigraine (ergotamine and caffeine) drug center > wigraine (ergotamine and caffeine) drug - warnings and precautions
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What is Raynaud's phenomenon?
Raynaud's phenomenon (RP) is a condition resulting in a particular series of discolorations of the fingers and/or the toes after exposure to changes in temperature (cold or hot) or emotional events. Skin discoloration occurs because an abnormal spasm of the blood vessels causes a diminished blood supply to the local tissues. Initially, the digit(s) involved turn white because of the diminished blood supply. The digit(s) then turn blue because of prolonged lack of oxygen. Finally, the blood vessels reopen, causing a local "flushing" phenomenon, which turns the digit(s) red. This three-phase color sequence (white to blue to red), most often upon exposure to cold temperature, is characteristic of RP.
Raynaud's phenomenon most frequently affects women, especially in the second, third, or fourth decades of life. People can have Raynauds phenomenon alone or as a part of other rheumatic diseases. When it occurs alone...
Wigraine
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Please Note: This Brand Name drug is no longer available in the US.(Generic versions may still be available.)
PRECAUTIONS
Although signs and symptoms of ergotism rarely develop even after long term intermittent use of the orally administered drug, care should be exercised to remain within the limits of recommended dosage.
Pregnancy Category X. See Contraindications section.
Nursing Mothers. It is not known whether the ergotamine tartrate in Wigraine (ergotamine and caffeine) ® is excreted in human milk. Because some ergot alkaloids have been found in the milk of nursing mothers resulting in symptoms of ergotism in their children, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Pediatric Usage. Safety and effectiveness in children have not been established.
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
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