"The US Food and Drug Administration (FDA) has approved a riboflavin ophthalmic solution (Photrexa, Avedro) that treats a corneal disease called progressive keratoconus with corneal collagen crosslinking, the manufacturer announced today."...
(latanoprost) Ophthalmic Solution
Latanoprost is a prostaglandin F2α analogue. Its chemical name is isopropyl-(Z)7[(1R,2R,3R,5S)3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5heptenoate. Its molecular formula is C26H40O5 and its chemical structure is:
Latanoprost is a colorless to slightly yellow oil that is very soluble in acetonitrile and freely soluble in acetone, ethanol, ethyl acetate, isopropanol, methanol, and octanol. It is practically insoluble in water.
XALATAN (latanoprost ophthalmic solution) 0.005% is supplied as a sterile, isotonic, buffered aqueous solution of latanoprost with a pH of approximately 6.7 and an osmolality of approximately 267 mOsmol/kg. Each mL of XALATAN contains 50 micrograms of latanoprost. Benzalkonium chloride, 0.02% is added as a preservative. The inactive ingredients are: sodium chloride, sodium dihydrogen phosphate monohydrate, disodium hydrogen phosphate anhydrous, and water for injection. One drop contains approximately 1.5 mcg of latanoprost.
What are the possible side effects of latanoprost ophthalmic (Xalatan, Xalatan Multi-Pack)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using latanoprost ophthalmic and call your doctor at once if you have any of these serious side effects:
- redness, swelling, itching, or pain in or around your eye;
- oozing or discharge from your eye;
- increased sensitivity to light;
- vision changes; or
- chest pain.
Less serious side effects may include:
- cold symptoms such as...
What are the precautions when taking latanoprost ophthalmic (Xalatan)?
Before using latanoprost, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: an active swelling process within the eye (e.g., iritis, uveitis).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems (e.g., macular edema, history of iritis/uveitis, lens extraction/aphakia), contact lens use.
If you develop an eye infection or...
Last reviewed on RxList: 12/16/2014
This monograph has been modified to include the generic and brand name in many instances.
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