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Apart from ocular irritation and conjunctival or episcleral hyperemia, the ocular effects of latanoprost administered at high doses are not known. Intravenous administration of large doses of latanoprost in monkeys has been associated with transient bronchoconstriction; however, in 11 patients with bronchial asthma treated with latanoprost, bronchoconstriction was not induced. Intravenous infusion of up to 3 μg/kg in healthy volunteers produced mean plasma concentrations 200 times higher than during clinical treatment and no adverse reactions were observed. Intravenous dosages of 5.5 to 10 μg/kg caused abdominal pain, dizziness, fatigue, hot flushes, nausea, and sweating.
If overdosage with XALATAN Sterile Ophthalmic Solution occurs, treatment should be symptomatic.
Known hypersensitivity to latanoprost, benzalkonium chloride, or any other ingredients in this product.
Last reviewed on RxList: 3/26/2012
This monograph has been modified to include the generic and brand name in many instances.
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