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Xalatan

"A study in mice reveals an elegant circuit within the developing visual system that helps dictate how the eyes connect to the brain. The research, funded by the National Institutes of Health, has implications for treating amblyopia, a vision diso"...

Xalatan

Side Effects
Interactions

SIDE EFFECTS

The following adverse reactions were reported in postmarketing experience and are discussed in greater detail in other sections of the label:

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, the adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

XALATAN was studied in three multicenter, randomized, controlled clinical trials. Patients received 50 mcg/mL XALATAN once daily or 5 mg/mL active-comparator (timolol) twice daily. The patient population studied had a mean age of 65±10 years. Seven percent of patients withdrew before the 6-month endpoint.

Table 1: Ocular Adverse Reactions and ocular signs/symptoms reported by 5-15% of patients receiving Latanoprost

Symptom/Finding Adverse Reactions (incidence (%))
Latanoprost (n=460) Timolol (n=369)
Foreign body sensation 13 8
Punctate epithelial keratopathy 10 9
Stinging 9 12
Conjunctival hyperemia 8 3
Blurred vision 8 8
Itching 8 8
Burning 7 8
Increased pigmentation of the iris 7 0

Less than 1% of the patients treated with XALATAN required discontinuation of therapy because of intolerance to conjunctival hyperemia.

Table 2: Adverse Reactions that were reported in 1-5% of patients receiving Latanoprost

  Adverse Reactions (incidence (%))
Latanoprost
(n=460)
Timolol
(n=369)
Ocular Events/Signs and Symptoms
  Excessive tearing 4 6
  Lid discomfort/pain 4 2
  Dry eye 3 3
  Eye pain 3 3
  Lid crusting 3 3
  Lid erythema 3 2
  Photophobia 2 1
  Lid edema 1 3
Systemic Events
  Upper respiratory tract infection/cold/flu 3 3
  Muscle/joint/back pain 1 0.5
  Rash/allergic skin reaction 1 0.3

Postmarketing Experience

The following reactions have been identified during postmarketing use of XALATAN in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. The reactions, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to XALATAN, or a combination of these factors, include:

Nervous System disorders: dizziness, headache, and toxic epidermal necrolysis

Eye Disorders: eyelash and vellus hair changes (increased length, thickness, pigmentation, and number); keratitis; corneal edema and erosions; intraocular inflammation (iritis/uveitis); macular edema, including cystoid macular edema; misdirected eyelashes sometimes resulting in eye irritation; periorbital and lid changes resulting in deepening of the eyelid sulcus

Respiratory, Thoracic and Mediastinal Disorders: asthma and exacerbation of asthma; dyspnea

Skin and Subcutaneous Tissue Disorders: eyelid skin darkening

Infections and Infestations: Herpes keratitis

Read the Xalatan (latanoprost ophthalmic) Side Effects Center for a complete guide to possible side effects

DRUG INTERACTIONS

In vitro studies have shown that precipitation occurs when eye drops containing thimerosal are mixed with XALATAN. If such drugs are used, they should be administered at least five (5) minutes apart.

The combined use of two or more prostaglandins, or prostaglandin analogs including XALATAN is not recommended. It has been shown that administration of these prostaglandin drug products more than once daily may decrease the IOP lowering effect or cause paradoxical elevations in IOP.

Read the Xalatan Drug Interactions Center for a complete guide to possible interactions

Last reviewed on RxList: 12/16/2014
This monograph has been modified to include the generic and brand name in many instances.

Side Effects
Interactions
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Xalatan - User Reviews

Xalatan User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Xalatan sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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