"The US Food and Drug Administration (FDA) has approved a riboflavin ophthalmic solution (Photrexa, Avedro) that treats a corneal disease called progressive keratoconus with corneal collagen crosslinking, the manufacturer announced today."...
Xalatan Side Effects Center
Pharmacy Editor: Charles Patrick Davis, MD, PhD
Xalatan (latanoprost) is a prostaglandin analogue ophthalmic solution used to treat pressure in the eye (glaucoma, ocular hypertension) by decreasing liquid in the eye. Xalantan is available as a generic drug named lantanoprost. Side effects of Xalatan include blurred vision, burning/stinging/itching/redness of the eye after using the drops, feeling as if something is in the eye, changes in eyelash number/color/length/thickness, eyelid skin darkening, browning of the iris, watery eyes, dry eyes, eye discomfort, lid crusting/discomfort, increased sensitivity to light, cold or flu-like symptoms (stuffy nose, sneezing, sore throat), headache, dizziness, or muscle/joint pain.
Xalatan (latanoprost) is available in an ophthalmic solution; strength is 0.005% (50 µg/mL). It is administered by an eyedropper. The amount is determined by the doctor. Serious side effects include oozing or eye discharge, chest pain, vision changes, light sensitivity and redness, swelling, itching or pain in the eye. Benefits versus risks should be considered in pregnant women; it is not known if the drug is present in breast milk. Use in pediatrics is not discussed; any use of this drug should be first discussed with a doctor, preferably an ophthalmologist.
Our Xalantan Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Xalatan in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using latanoprost ophthalmic and call your doctor at once if you have any of these serious side effects:
- redness, swelling, itching, or pain in or around your eye;
- oozing or discharge from your eye;
- increased sensitivity to light;
- vision changes; or
- chest pain.
Less serious side effects may include:
- cold symptoms such as stuffy nose, sneezing, sore throat;
- headache, dizziness;
- mild eye discomfort;
- blurred vision;
- feeling like something is in your eye;
- dry or watery eyes; or
- stinging or burning of the eyes after using the drops.
Read the entire detailed patient monograph for Xalatan (Latanoprost Ophthalmic)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Xalatan Overview - Patient Information: Side Effects
This medication may slowly (over months to years) cause brown discoloration of the colored portion of the eye (iris). If you are using latanoprost in only one eye, only that iris may change color. This color change may be permanent but the long-term effects are uncertain. Notify your doctor if this occurs and schedule regular eye exams to monitor it.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: eye pain, suspected eye infection (unusual redness or swelling of eyes), chest pain.
Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: rapid vision changes (e.g., loss of vision).
A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, severe itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Xalatan (Latanoprost Ophthalmic)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Xalatan FDA Prescribing Information: Side Effects
The following adverse reactions were reported in postmarketing experience and are discussed in greater detail in other sections of the label:
- Iris pigmentation changes [see WARNINGS AND PRECAUTIONS]
- Eyelid skin darkening [see WARNINGS AND PRECAUTIONS]
- Eyelash changes (increased length, thickness, pigmentation, and number of lashes) [see WARNINGS AND PRECAUTIONS]
- Intraocular inflammation (iritis/uveitis) [see WARNINGS AND PRECAUTIONS]
- Macular edema, including cystoid macular edema [see WARNINGS AND PRECAUTIONS]
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, the adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
XALATAN was studied in three multicenter, randomized, controlled clinical trials. Patients received 50 mcg/mL XALATAN once daily or 5 mg/mL active-comparator (timolol) twice daily. The patient population studied had a mean age of 65±10 years. Seven percent of patients withdrew before the 6-month endpoint.
Table 1: Ocular Adverse Reactions and ocular signs/symptoms
reported by 5-15% of patients receiving Latanoprost
|Symptom/Finding||Adverse Reactions (incidence (%))|
|Latanoprost (n=460)||Timolol (n=369)|
|Foreign body sensation||13||8|
|Punctate epithelial keratopathy||10||9|
|Increased pigmentation of the iris||7||0|
Less than 1% of the patients treated with XALATAN required discontinuation of therapy because of intolerance to conjunctival hyperemia.
Table 2: Adverse Reactions
that were reported in 1-5% of patients receiving Latanoprost
|Adverse Reactions (incidence (%))|
|Ocular Events/Signs and Symptoms|
|Upper respiratory tract infection/cold/flu||3||3|
|Rash/allergic skin reaction||1||0.3|
The following reactions have been identified during postmarketing use of XALATAN in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. The reactions, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to XALATAN, or a combination of these factors, include:
Nervous System disorders: dizziness, headache, and toxic epidermal necrolysis
Eye Disorders: eyelash and vellus hair changes (increased length, thickness, pigmentation, and number); keratitis; corneal edema and erosions; intraocular inflammation (iritis/uveitis); macular edema, including cystoid macular edema; misdirected eyelashes sometimes resulting in eye irritation; periorbital and lid changes resulting in deepening of the eyelid sulcus
Skin and Subcutaneous Tissue Disorders: eyelid skin darkening
Infections and Infestations: Herpes keratitis
Read the entire FDA prescribing information for Xalatan (Latanoprost Ophthalmic)
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