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Xalkori Patient Information including If I Miss a Dose
In this Article
- What is crizotinib (Xalkori)?
- What are the possible side effects of crizotinib (Xalkori)?
- What is the most important information I should know about crizotinib (Xalkori)?
- What should I discuss with my healthcare provider before taking crizotinib (Xalkori)?
- How should I take crizotinib (Xalkori)?
- What happens if I miss a dose (Xalkori)?
- What happens if I overdose (Xalkori)?
- What should I avoid while taking crizotinib (Xalkori)?
- What other drugs will affect crizotinib (Xalkori)?
- Where can I get more information?
What happens if I miss a dose (Xalkori)?
Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 6 hours away. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Xalkori)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking crizotinib (Xalkori)?
Grapefruit and grapefruit juice may interact with crizotinib and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.
What other drugs will affect crizotinib (Xalkori)?
Many drugs can interact with crizotinib. Below is just a partial list. Tell your doctor if you are using:
- a blood thinner such as warfarin (Coumadin, Jantoven);
- cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) or tacrolimus (Prograf);
- dexamethasone (Cortastat, Dexasone, Solurex, DexPak);
- digoxin (digitalis, Lanoxin, Lanoxicaps);
- isoniazid (for treating tuberculosis);
- nicardipine (Cardene);
- pimozide (Orap);
- St. John's wort;
- theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl);
- an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), rifapentine (Priftin), or telithromycin (Ketek);
- an antidepressant such as citalopram (Celexa), desipramine (Norpramin), doxepin (Sinequan, Silenor), escitalopram (Lexapro), mirtazapine (Remeron), nefazodone, sertraline (Zoloft), trazodone (Desyrel, Oleptro), trimipramine (Surmontil), or venlafaxine (Effexor);
- antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);
- a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);
- ergot medicine such as ergotamine (Ergomar, Cafergot) or dihydroergotamine (D.H.E. 45, Migranal Nasal Spray);
- a heart rhythm medication such as disopyramide (Norpace), procainamide (Procan, Pronestyl), or quinidine (Quin-G);
- HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), etravirine (Intelence), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, Kaletra), or saquinavir (Invirase); or
- seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), divalproex (Depakote), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), primidone (Mysoline), or valproic acid (Depakene, Stavzor).
This list is not complete and there are many other drugs that can interact with crizotinib. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
Where can I get more information?
Your pharmacist can provide more information about crizotinib.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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Additional Xalkori Information
- Xalkori Drug Interactions Center: crizotinib oral
- Xalkori Side Effects Center
- Xalkori FDA Approved Prescribing Information including Dosage
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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