May 29, 2017
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Overdose of XARELTO may lead to hemorrhage. Discontinue XARELTO and initiate appropriate therapy if bleeding complications associated with overdosage occur. A specific antidote for rivaroxaban is not available. Rivaroxaban systemic exposure is not further increased at single doses > 50 mg due to limited absorption. The use of activated charcoal to reduce absorption in case of XARELTO overdose may be considered. Due to the high plasma protein binding, rivaroxaban is not dialyzable [see WARNINGS AND PRECAUTIONS and CLINICAL PHARMACOLOGY]. Partial reversal of laboratory anticoagulation parameters may be achieved with use of plasma products.


XARELTO is contraindicated in patients with:

  • active pathological bleeding [see WARNINGS AND PRECAUTIONS]
  • severe hypersensitivity reaction to XARELTO (e.g., anaphylactic reactions) [see ADVERSE REACTIONS]
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 4/17/2017


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