Xenon Xe 133 Gas
"On December 21, the U.S. Food and Drug Administration approved Uptravi (selexipag) tablets to treat adults with pulmonary arterial hypertension (PAH), a chronic, progressive, and debilitating rare lung disease that can lead to death or the need f"...
Xenon Xe 133 Gas
XENON Xe 133 Gas
For Diagnostic Use
XENON Xe 133 Gas is supplied in a mixture of xenon gas (5%) in carbon dioxide (95%). It is contained within septum sealed glass vials and is suitable for inhalation in the diagnostic evaluation of pulmonary function and imaging, as well as assessment of cerebral blood flow. Xenon Xe 133 Gas is reactorproduced as a by-product of Uranium U235 fission. Each vial contains the labeled amount of Xenon Xe 133 radioactivity at the time of calibration. The contents of the vial are in gaseous form, contain no preservatives, and are ready for use.
Xenon Xe 133 is chemically and physiologically related to elemental Xenon, a non-radioactive monoatomic gas which is physiologically inert except for anesthetic properties at high doses.
Xenon Xe 133 decays by beta and gamma emissions with a half-life of 5.245 days1. Significant radiations which are emitted by the nuclide are listed in Table 1.
Table 1: Principal Radiation Emis s ion Data from
|Radiation||Mean Energy (KeV)||Mean % per Disintegration|
The specific gamma ray constant for Xenon Xe 133 is 3.6 microcoulombs/Kg-MBq-hr (0.51R/hr-mCi) at 1 cm. The first half value thickness of lead is 0.0035 cm. A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from the interposition of various thicknesses of Pb is shown in Table 2. For example, the use of 0.20 cm of Pb will decrease the external radiation exposure by a factor of 1,000.
Table 2: Radiation Attenuation by Lead Shielding
|cm of Pb||Radiation Attenuation Factor|
To correct for physical decay of this radionuclide, the fractions that remain at selected time intervals after the time of calibration are shown in Table 3.
Table 3: Xenon Xe 133 Phys ical Decay Chart (Half Life
5.245 days )
|Day||Fraction Remaining||Day||Fraction Remaining|
|* Calibration Day|
1 Kocher, David C., “Radioactive Decay Data Tables,” DOE/TIC-11026, p. 138,1981.
Last reviewed on RxList: 1/5/2017
This monograph has been modified to include the generic and brand name in many instances.
Additional Xenon Xe 133 Gas Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Find out what women really need.