Xenon Xe 133 Gas
"The US Food and Drug Administration (FDA) has expanded the indication for the short-acting beta-agonist albuterol sulfate inhalation powder (ProAir RespiClick, Teva) to children aged 4 to 11 years, the company announced today.
Xenon Xe 133 Gas
Inhalation of Xenon Xe 133 Gas has proved valuable for the evaluation of pulmonary function and for imaging the lungs. It may also be applied to assessment of cerebral flow.
DOSAGE AND ADMINISTRATION
Xenon Xe 133 gas is administered by inhalation from closed respirator systems or spirometers.
The suggested activity range employed for inhalation by the average adult patient (70 kg) is:
Pulmonary function including imaging: 74-1110MBq (2-30mCi) in 3 liters of air.
Cerebral blood flow: 370-1110MBq (10-30mCi) in 3 liters of air.
The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration.
The estimated absorbed radiation doses2 to an average patient (70 kg) for pulmonary perfusion and cerebral blood flow studies from a maximum dose of 1110 MBq (30mCi) of Xenon Xe 133 in 3 liters of air are shown in Table 4.
Table 4: Radiation Doses
|Effective Half-Time||Lungs*||Brainm Gy/1110MBq||Whole Body (rads/30mCi)|
|*99% of activity is in lungs.|
2Method of Calculation: A Schema for Absorbed-Dose Calculation for Biologically Distributed Radionuclides, Supplement No. 1, MIRD pamphlet No. 1, J. Nucl. Med., p.7 (1968).
The Xenon Xe 133 gas is supplied as part of the Calidose™ system, consisting of 3ml unit dose vials and the Calidose™ dispenser for shielded dispensing.
Normally vials containing either 370 or 740MBq (10 or 20mCi)/vial, packed 1 vial or 5 vials per shield tube, are supplied.
The NDC number for: 10mCi vial is 11994-127; 20mCi vial is 11994-128.
Store at controlled room temperature 20°-25°C (68°-77°F) [See USP].
This radiopharmaceutical is approved for distribution to persons licensed pursuant to the Code of Massachusetts Regulations 105 CMR 120.100 for the uses listed in 105 CMR 120. 547 or 120.552 or under equivalent regulations of the U.S. Nuclear Regulatory Commission, an Agreement State, or a Licensing State.
The contents of the vial are radioactive. Adequate shielding and handling precautions must be maintained.
Lantheus Medical Imaging, 331 Treble Cove Rd., N. Billerica, MA 01862 USAM For Ordering Tel. Toll Free 800-299-3431 (For Massachusetts and International, Call 978-667-9531), All Other Business 800-362-2668. Revised: Aug 2011This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 4/4/2016
Additional Xenon Xe 133 Gas Information
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