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(acyclovir and hydrocortisone) Cream 5%/1%


XERESE contains acyclovir, a synthetic nucleoside analogue active against herpes viruses, and hydrocortisone, an anti-inflammatory corticosteroid, combined in a cream for topical administration. Each gram of XERESE contains 5% (w/w) of acyclovir, 1% (w/w) of hydrocortisone and the following inactive ingredients: cetostearyl alcohol, mineral oil, Poloxamer 188, propylene glycol, isopropyl myristate, sodium lauryl sulfate, white petrolatum, citric acid, sodium hydroxide and water. Sodium hydroxide or hydrochloric acid may have been added to adjust the pH to approximately pH 5.

Acyclovir, 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one, is a synthetic nucleoside analogue active against herpes viruses. The maximum solubility of acyclovir in water at 37°C is 2.5 mg/mL. The pKa's of acyclovir are 2.27 and 9.25. Its empirical formula is C8H11N5O3. The structural formula is provided in Figure 1:

Figure 1: Strutural Formula of Acyclovir

Acyclovir - Structural Formula Illustration

Hydrocortisone, pregn-4-ene-3, 20-dione, 11, 17, 21-trihydroxy-(11(beta))-, is an anti-inflammatory corticosteroid. Its empirical formula is C21H30O5. The structural formula is provided in Figure 2:

Figure 2: Strutural Formula of Hydrocortisone

Hydrocortisone - Structural Formula Illustration

What are the possible side effects of acyclovir and hydrocortisone topical (Xerese)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have severe burning, stinging, or irritation of treated skin.

Less serious side effects may include:

  • mild burning or tingling after applying the medicine;
  • skin dryness or flaking;
  • bitter taste in your mouth after applying the medicine; or
  • skin redness or discoloration;

This is not a...

Read All Potential Side Effects and See Pictures of Xerese »

Last reviewed on RxList: 10/31/2016
This monograph has been modified to include the generic and brand name in many instances.

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