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Advise patients to contact a healthcare professional for any of the following:
- Symptoms of a hypersensitivity reaction, including rash, urticaria, pruritus, lip swelling, shortness of breath, hypotension and respiratory tract edema. [see CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, and ADVERSE REACTIONS]
- Symptoms of hypocalcemia, including paresthesias or muscle stiffness, twitching, spasms, or cramps [see CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, and ADVERSE REACTIONS]
- Symptoms of ONJ, including pain, numbness, swelling of or drainage from the jaw, mouth, or teeth [see WARNINGS AND PRECAUTIONS and ADVERSE REACTIONS]
- Persistent pain or slow healing of the mouth or jaw after dental surgery [see WARNINGS AND PRECAUTIONS]
- Symptoms of atypical femoral fracture, including new or unusual thigh, hip, or groin pain [see WARNINGS AND PRECAUTIONS]
- Pregnancy or nursing [see WARNINGS AND PRECAUTIONS and Use In Specific Populations]
Advise patients of the need for:
- Avoiding therapy with Xgeva if a serious allergic reaction occurred with prior Xgeva or Prolia therapy [see CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS]
- Proper oral hygiene and routine dental care
- Informing their dentist that they are receiving Xgeva
- Avoiding invasive dental procedures during treatment with Xgeva
- The use of highly effective contraception during and for at least 5 months after treatment with Xgeva for females of reproductive potential.
Last reviewed on RxList: 12/18/2014
This monograph has been modified to include the generic and brand name in many instances.
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