May 29, 2017




The effects of overdose of XIAFLEX are unknown. It is possible that multiple simultaneous or excessive doses of XIAFLEX may cause more severe local effects than the recommended doses including serious adverse reactions in the injected area (e.g., tendon ruptures or corporal ruptures dependent on the injection site). Supportive care and symptomatic treatment are recommended in these circumstances.


XIAFLEX is contraindicated in:

  • the treatment of Peyronie’s plaques that involve the penile urethra due to potential risk to this structure.
  • patients with a history of hypersensitivity to XIAFLEX or to collagenase used in any other therapeutic application or application method [see WARNINGS AND PRECAUTIONS].
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 12/8/2016


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