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home > drugs a-z list > xifaxan (rifaximin) drug center > xifaxan (rifaximin) drug - overdosage and contraindications
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Xifaxan
E. coli 0157:H7 Facts
- E. coli 0157:H7 is a gram-negative bacterium that can produce a bloody diarrhea due to toxins it secretes when it infects human intestinal tracts.
- The symptoms of E. coli 0157:H7 infection may include a low fever, nausea, vomiting, stomach cramps, and bloody diarrhea.
- E. coli 0157:H7 is notorious because it can cause additional complications in children and the elderly; renal failure, anemia, and dehydration especially for children (termed HUS or Hemolytic-uremic syndrome) and spontaneous bleeding, organ failures, and mental changes in the elderly (termed TTP or thrombotic thrombocytopenic purpura). Some of these patients develop disabilities or die.
- Diagnosis is definitively made when E. coli 0157:H7 is isolated, usually from the patient's stool, and identified as serotype 0157 by immunologic tests.
- Most E. coli 0157:H7 infections resolve s...
Xifaxan
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OVERDOSE
No specific information is available on the treatment of overdosage with XIFAXAN (rifaximin) . In clinical studies at doses higher than the recommended dose ( > 600 mg/day for travelers' diarrhea or > 1100 mg/day for hepatic encephalopathy), adverse reactions were similar in subjects who received doses higher than the recommended dose and placebo. In the case of overdosage, discontinue XIFAXAN (rifaximin) , treat symptomatically, and institute supportive measures as required.
CONTRAINDICATIONS
Hypersensitivity
XIFAXAN (rifaximin) is contraindicated in patients with a hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN (rifaximin) . Hypersensitivity reactions have included exfoliative dermatitis, angioneurotic edema, and anaphylaxis [see ADVERSE REACTIONS].
Last reviewed on RxList: 4/19/2010
This monograph has been modified to include the generic and brand name in many instances.
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