(minocycline hydrochloride) Extended-Release Capsules, for Oral Use


The active ingredient in Ximino Extended-Release Capsules is minocycline hydrochloride, a semi synthetic derivative of tetracycline. Ximino is a tetracycline-class drug. Ximino is known chemically as [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-l,4,4a,5,5a,6,l l,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11 -dioxo-2-naphthacenecarboxamide mono hydrochloride. The structural formula is represented below:

XEMINO (minocycline hydrochloride) Structural Formula Illustration

C23H27N3O7•HCl ................M.W. 493.95

Minocycline hydrochloride, USP is a yellow crystalline powder, sparingly soluble in water, soluble in solutions of alkali hydroxides and carbonates, slightly soluble in alcohol, practically insoluble in chloroform and in ether.

Ximino (minocycline hydrochloride) Extended-Release Capsules for oral administration contain minocycline hydrochloride, USP equivalent to 45 mg, 67.5 mg, 90 mg, 112.5 mg, or 135 mg of minocycline. The Extended-Release Capsules contain the following inactive ingredients: colloidal silicon dioxide, D&C Yellow #10 (in 45 mg strength), FD&C Blue #1, FD&C Yellow #6 (in 45 mg, 67.5 mg, and 135 mg strength), gelatin, hypromellose, lactose monohydrate, magnesium stearate, sodium lauryl sulfate, and titanium dioxide.

The 45 mg, 67.5 mg, 90 mg, 112.5 mg, and 135 mg capsules also contain Opadry Clear which contains hypromellose, polyethylene glycol 400, polyethylene glycol 6000, and talc.

Ximino Extended-Release Capsules also contain black ink which contains black iron oxide, potassium hydroxide, propylene glycol, and shellac.

Last reviewed on RxList: 7/30/2012
This monograph has been modified to include the generic and brand name in many instances.


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