Xolegel (Ketoconazole) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Xolegel

Dandruff (Seborrhea) »

What is dandruff (seborrhea)?

It is a common form of skin eczema that occurs in parts of the body with high oil (sebum) production. Body areas that are commonly affected include the scalp, ears, face, chest, and folds of skin, such as the underarms or the skin below breasts or overhanging abdominal folds. The cause of seborrhea is unknown, although a yeast that often lives on the skin, Malassezia furfur, may play a role.

One common manifestation of seborrhea that affects the scalp is dandruff. Scalp seborrhea can also present as thick, flaky, localized patches of scale. On the face, seborrhea produces reddish-brown, dry-looking, or thick, greasy scales on the eyebrows, sides of the nose, and behind the ears. Reddish, scaly patches may also appear in the folds of skin mentioned above. Although skin affected by seborrhea may feel "dry," moisturizing only makes them redder.

Scalp seborrhea and dandruff do not cause perm...

Read the Dandruff (Seborrhea) article »

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Xolegel

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XOLEGEL®
(ketoconazole) Gel 2%

DRUG DESCRIPTION

XOLEGEL contains the antifungal agent ketoconazole USP at 2% in a topical anhydrous gel vehicle for topical administration.

Chemically, ketoconazole is (±)-cis-1 -Acetyl-4-[p-[[2-(2,4-dichlorophenyl)-2-(lH-imidazol-1 -ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, with the molecular formula C₂₆H₂₈Cl₂N₄O₄ and a molecular weight of 531.43.

Figure 1

KLONOPIN® Structural Formula Illustration

Each gram contains: 20 mg ketoconazole USP, dehydrated alcohol (34%), ascorbic acid, butylated hydroxytoluene, citric acid monohydrate, glycerin, hydroxypropyl cellulose, polyethylene glycol 400, PPG-15 stearyl ether, propylene glycol, FD&C yellow No. 6, and FD&C yellow No. 10.

XOLEGEL (ketoconazole) is a smooth, translucent to clear, amber gel.

What are the possible side effects of ketoconazole topical (Extina, Kuric, Nizoral A-D, Nizoral Topical, Xolegel)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using ketoconazole topical and call your doctor if you have any of these serious side effects:

severe itching, burning, or irritation where the medicine is applied;
oily or dry scalp, mild hair loss;
redness, pain, or oozing of treated skin areas; or
eye redness, swelling, or...

Read All Potential Side Effects and See Pictures of Xolegel »

What are the precautions when taking ketoconazole (Xolegel)?

Before using ketoconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals such as clotrimazole, econazole, or miconazole; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before...

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Last reviewed on RxList: 1/31/2011
This monograph has been modified to include the generic and brand name in many instances.