"The cystic fibrosis (CF) drug Orkambi (Vertex Pharmaceuticals) has received a green light from the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP).
Orkambi is a fixed-dose oral combination "...
(lidocaine HCl) Injection, USP
(lidocaine HCl and epinephrine) Injection, USP
For Infiltration and Nerve Block
Xylocaine (lidocaine HCl) Injections are sterile, nonpyrogenic, aqueous solutions that contain a local anesthetic agent with or without epinephrine and are administered parenterally by injection.
See INDICATIONS for specific uses.
Xylocaine solutions contain lidocaine HCl, which is chemically designated as acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride and has the molecular wt. 270.8.
Lidocaine HCl (C14H22N2O•HCl) has the following structural formula:
Epinephrine is (-) -3, 4-Dihydroxy-α-[(methylamino) methyl] benzyl alcohol and has the molecular wt. 183.21. Epinephrine (C9H13NO3) has the following structural formula:
Dosage forms listed as Xylocaine (lidocaine) -MPF indicate single dose solutions that are Methyl Paraben Free (MPF).
Xylocaine (lidocaine) MPF is a sterile, nonpyrogenic, isotonic solution containing sodium chloride. Xylocaine (lidocaine) in multiple dose vials: Each mL also contains 1 mg methylparaben as antiseptic preservative. The pH of these solutions is adjusted to approximately 6.5 (5.0–7.0) with sodium hydroxide and/or hydrochloric acid.
Xylocaine (lidocaine) MPF with Epinephrine is a sterile, nonpyrogenic, isotonic solution containing sodium chloride. Each mL contains lidocaine hydrochloride and epinephrine, with 0.5 mg sodium metabisulfite as an antioxidant and 0.2 mg citric acid as a stabilizer. Xylocaine (lidocaine) with Epinephrine in multiple dose vials: Each mL also contains 1 mg methylparaben as antiseptic preservative. The pH of these solutions is adjusted to approximately 4.5 (3.3–5.5) with sodium hydroxide and/or hydrochloric acid. Filled under nitrogen.
What are the possible side effects of lidocaine injection (Anestacaine, UAD Caine, Xylocaine HCl, Xylocaine-MPF)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have any of these serious side effects:
- feeling anxious, shaky, dizzy, restless, or depressed;
- drowsiness, vomiting, ringing in your ears, blurred vision;
- confusion, twitching, seizure (convulsions);
- fast heart rate, rapid breathing, feeling hot or cold;
- weak or shallow breathing, slow heart...
Last reviewed on RxList: 1/10/2011
This monograph has been modified to include the generic and brand name in many instances.
Additional Xylocaine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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