Xylocaine (lidocaine HCl) Injections are sterile, nonpyrogenic, aqueous solutions that contain a local anesthetic agent with or without epinephrine and are administered parenterally by injection.

See INDICATIONS for specific uses.

Xylocaine solutions contain lidocaine HCl, which is chemically designated as acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride and has the molecular wt. 270.8.

Lidocaine HCl (C₁₄H₂₂N₂O•HCl) has the following structural formula:

Epinephrine is (-) -3, 4-Dihydroxy-α-[(methylamino) methyl] benzyl alcohol and has the molecular wt. 183.21. Epinephrine (C₉H₁₃NO₃) has the following structural formula:

Dosage forms listed as Xylocaine (lidocaine) -MPF indicate single dose solutions that are Methyl Paraben Free (MPF).

Xylocaine (lidocaine) MPF is a sterile, nonpyrogenic, isotonic solution containing sodium chloride. Xylocaine (lidocaine) in multiple dose vials: Each mL also contains 1 mg methylparaben as antiseptic preservative. The pH of these solutions is adjusted to approximately 6.5 (5.0–7.0) with sodium hydroxide and/or hydrochloric acid.

Xylocaine (lidocaine) MPF with Epinephrine is a sterile, nonpyrogenic, isotonic solution containing sodium chloride. Each mL contains lidocaine hydrochloride and epinephrine, with 0.5 mg sodium metabisulfite as an antioxidant and 0.2 mg citric acid as a stabilizer. Xylocaine (lidocaine) with Epinephrine in multiple dose vials: Each mL also contains 1 mg methylparaben as antiseptic preservative. The pH of these solutions is adjusted to approximately 4.5 (3.3–5.5) with sodium hydroxide and/or hydrochloric acid. Filled under nitrogen.

Last reviewed on RxList: 1/10/2011
This monograph has been modified to include the generic and brand name in many instances.