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Xylocaine MPF Sterile Solution

Last reviewed on RxList: 12/21/2016
Xylocaine MPF Sterile Solution Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 5/12/2016

4% Xylocaine-MPF (lidocaine HCl) Sterile Solution is a local anesthetic used to numb an area of your body to help reduce pain or discomfort caused by invasive medical procedures such as surgery, needle punctures, or insertion of a catheter or breathing tube. 4% Xylocaine-MPF is also given in an epidural (spinal block) to reduce the discomfort of contractions during labor, and is sometimes used to treat irregular heart rhythms that may signal a possible heart attack. 4% Xylocaine-MPF is available in generic form. Common side effects of 4% Xylocaine-MPF include:

  • injection site reactions (bruising, redness, itching, or swelling)
  • dizziness
  • nausea, and
  • numbness in places where the medicine is accidentally applied

The dosage of 4% Xylocaine-MPF varies and depends upon the area to be anesthetized, vascularity of the tissues, individual tolerance and the technique of anesthesia. Xylocaine-MPF may interact with other drugs. Tell your doctor all medications and supplements you use. Xylocaine-MPF is not expected to be harmful to a fetus. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our 4% Xylocaine-MPF (lidocaine HCl) Sterile Solution Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Xylocaine MPF Sterile Solution Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • feeling anxious, shaky, dizzy, restless, or depressed;
  • drowsiness, vomiting, ringing in your ears, blurred vision;
  • confusion, twitching, seizure (convulsions);
  • fast heart rate, rapid breathing, feeling hot or cold;
  • weak or shallow breathing, slow heart rate, weak pulse; or
  • feeling like you might pass out.

Less serious side effects include:

  • mild bruising, redness, itching, or swelling where the medication was injected;
  • mild dizziness;
  • nausea;
  • numbness in places where the medicine is accidentally applied.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Xylocaine MPF Sterile Solution (Lidocaine HCl Sterile Solution)

Xylocaine MPF Sterile Solution Professional Information

SIDE EFFECTS

Adverse experiences following the administration of lidocaine are similar in nature to those observed with other amide local anesthetic agents. These adverse experiences are, in general, dose-related and may result from high plasma levels caused by excessive dosage, rapid absorption or inadvertent intravascular injection, or may result from a hypersensitivity, idiosyncrasy or diminished tolerance on the part of the patient. Serious adverse experiences are generally systemic in nature. The following types are those most commonly reported:

Central Nervous System

CNS manifestations are excitatory and/or depressant and may be characterized by lightheadedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression and arrest. The excitatory manifestations may be very brief or may not occur at all, in which case the first manifestation of toxicity may be drowsiness merging into unconsciousness and respiratory arrest.

Drowsiness following the administration of lidocaine is usually an early sign of a high blood level of the drug and may occur as a consequence of rapid absorption.

Cardiovascular System

Cardiovascular manifestations are usually depressant and are characterized by bradycardia, hypotension, and cardiovascular collapse, which may lead to cardiac arrest.

Allergic

Allergic reactions are characterized by cutaneous lesions, urticaria, edema or anaphylactoid reactions. Allergic reactions as a result of sensitivity to lidocaine are extremely rare and, if they occur, should be managed by conventional means. The detection of sensitivity by skin testing is of doubtful value.

Neurologic

The incidences of adverse reactions associated with the use of local anesthetics may be related to the total dose of local anesthetic administered and are also dependent upon the particular drug used, the route of administration and the physical status of the patient.

There have been reported cases of permanent injury to extraocular muscles requiring surgical repair following retrobulbar administration.

Read the entire FDA prescribing information for Xylocaine MPF Sterile Solution (Lidocaine HCl Sterile Solution)

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© Xylocaine MPF Sterile Solution Patient Information is supplied by Cerner Multum, Inc. and Xylocaine MPF Sterile Solution Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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