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Xylocaine

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Xylocaine

Xylocaine Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Xylocaine (lidocaine HCl) Injection is used for local or regional anesthesia. It is a local anesthetic. This medication is available in generic form. Common side effects include nausea. Unlikely but serious side effects include drowsiness, mental/mood changes, ringing in the ears, dizziness, vision changes, tremors, numbness, headache, or backache.

For normal healthy adults, the individual maximum recommended dose of Xylocaine should not exceed 4.5 mg/kg (2 mg/lb) of body weight, and in general it is recommended that the maximum total dose does not exceed 300 mg. Xylocaine may interact with monoamine oxidase inhibitors (MAOIs), antidepressants, phenothiazines, butyrophenones, vasopressor drugs, ergot-type oxytocic drugs, or drugs that can cause drowsiness such as medicine for sleep, sedatives, tranquilizers, anti-anxiety drugs, narcotics, psychiatric medicines, anti-seizure drugs, muscle relaxants, or antihistamines. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant before using Xylocaine. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Our Xylocaine (lidocaine HCl) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Xylocaine in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • feeling anxious, shaky, dizzy, restless, or depressed;
  • drowsiness, vomiting, ringing in your ears, blurred vision;
  • confusion, twitching, seizure (convulsions);
  • fast heart rate, rapid breathing, feeling hot or cold;
  • weak or shallow breathing, slow heart rate, weak pulse; or
  • feeling like you might pass out.

Less serious side effects include:

  • mild bruising, redness, itching, or swelling where the medication was injected;
  • mild dizziness;
  • nausea;
  • numbness in places where the medicine is accidentally applied.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Xylocaine (Lidocaine) »

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Xylocaine FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Systemic

Adverse experiences following the administration of lidocaine HCl are similar in nature to those observed with other amide local anesthetic agents. These adverse experiences are, in general, dose-related and may result from high plasma levels caused by excessive dosage, rapid absorption or inadvertent intravascular injection, or may result from a hypersensitivity, idiosyncrasy or diminished tolerance on the part of the patient. Serious adverse experiences are generally systemic in nature. The following types are those most commonly reported:

Central Nervous System

CNS manifestations are excitatory and/or depressant and may be characterized by lightheadedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression and arrest. The excitatory manifestations may be very brief or may not occur at all, in which case the first manifestation of toxicity may be drowsiness merging into unconsciousness and respiratory arrest.

Drowsiness following the administration of lidocaine HCl is usually an early sign of a high blood level of the drug and may occur as a consequence of rapid absorption.

Cardiovascular System

Cardiovascular manifestations are usually depressant and are characterized by bradycardia, hypotension, and cardiovascular collapse, which may lead to cardiac arrest.

Allergic

Allergic reactions are characterized by cutaneous lesions, urticaria, edema or anaphylactoid reactions. Allergic reactions may occur as a result of sensitivity either to local anesthetic agents or to the methylparaben used as a preservative in the multiple dose vials. Allergic reactions as result of sensitivity to lidocaine HCl are extremely rare and, if they occur, should be managed by conventional means. The detection of sensitivity by skin testing is of doubtful value.

Neurologic

The incidences of adverse reactions associated with the use of local anesthetics may be related to the total dose of local anesthetic administered and are also dependent upon the particular drug used, the route of administration and the physical status of the patient. In a prospective review of 10,440 patients who received lidocaine HCl for spinal anesthesia, the incidences of adverse reactions were reported to be about 3 percent each for positional headaches, hypotension and backache; 2 percent for shivering; and less than 1 percent each for peripheral nerve symptoms, nausea, respiratory inadequacy and double vision. Many of these observations may be related to local anesthetic techniques, with or without a contribution from the local anesthetic.

In the practice of caudal or lumbar epidural block, occasional unintentional penetration of the subarachnoid space by the catheter may occur. Subsequent adverse effects may depend partially on the amount of drug administered subdurally. These may include spinal block of varying magnitude (including total spinal block), hypotension secondary to spinal block, loss of bladder and bowel control, and loss of perineal sensation and sexual function. Persistent motor, sensory and/or autonomic (sphincter control) deficit of some lower spinal segments with slow recovery (several months) or incomplete recovery have been reported in rare instances when caudal or lumbar epidural block has been attempted. Backache and headache have also been noted following use of these anesthetic procedures.

There have been reported cases of permanent injury to extraocular muscles requiring surgical repair following retrobulbar administration.

Read the entire FDA prescribing information for Xylocaine (Lidocaine) »

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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