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Xyzal

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Xyzal

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OVERDOSE

Overdosage has been reported with XYZAL (levocetirizine dihydrochloride) .

Symptoms of overdose may include drowsiness in adults and initially agitation and restlessness, followed by drowsiness in children. There is no known specific antidote to XYZAL (levocetirizine dihydrochloride) . Should overdose occur, symptomatic or supportive treatment is recommended. XYZAL (levocetirizine dihydrochloride) is not effectively removed by dialysis, and dialysis will be ineffective unless a dialyzable agent has been concomitantly ingested.

The acute maximal non-lethal oral dose of levocetirizine was 240 mg/kg in mice (approximately 190 times the maximum recommended daily oral dose in adults, approximately 230 times the maximum recommended daily oral dose in children 6 to 11 years of age, and approximately 180 times the maximum recommended daily oral dose in children 6 months to 5 years of age on a mg/m2 basis). In rats the maximal non-lethal oral dose was 240 mg/kg (approximately 390 times the maximum recommended daily oral dose in adults, approximately 460 times the maximum recommended daily oral dose in children 6 to 11 years of age, and approximately 370 times the maximum recommended daily oral dose in children 6 months to 5 years of age on a mg/m2 basis).

CONTRAINDICATIONS

The use of XYZAL (levocetirizine dihydrochloride) is contraindicated in:

Patients with known hypersensitivity

Patients with known hypersensitivity to levocetirizine or any of the ingredients of XYZAL (levocetirizine dihydrochloride) , or to cetirizine. Observed reactions range from urticaria to anaphylaxis [see ADVERSE REACTIONS].

Patients with end-stage renal disease

Patients with end-stage renal disease (CLCR < 10 mL/min) and patients undergoing hemodialysis

Pediatric patients with impaired renal function

Children 6 months to 11 years of age with impaired renal function

Last reviewed on RxList: 5/2/2011
This monograph has been modified to include the generic and brand name in many instances.

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