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Xyzal

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Xyzal

Overdosage
Contraindications

OVERDOSE

Overdosage has been reported with XYZAL.

Symptoms of overdose may include drowsiness in adults and initially agitation and restlessness, followed by drowsiness in children. There is no known specific antidote to XYZAL. Should overdose occur, symptomatic or supportive treatment is recommended. XYZAL is not effectively removed by dialysis, and dialysis will be ineffective unless a dialyzable agent has been concomitantly ingested.

The acute maximal non-lethal oral dose of levocetirizine was 240 mg/kg in mice (approximately 190 times the maximum recommended daily oral dose in adults, approximately 230 times the maximum recommended daily oral dose in children 6 to 11 years of age, and approximately 180 times the maximum recommended daily oral dose in children 6 months to 5 years of age on a mg/m² basis). In rats the maximal non-lethal oral dose was 240 mg/kg (approximately 390 times the maximum recommended daily oral dose in adults, approximately 460 times the maximum recommended daily oral dose in children 6 to 11 years of age, and approximately 370 times the maximum recommended daily oral dose in children 6 months to 5 years of age on a mg/m² basis).

CONTRAINDICATIONS

The use of XYZAL is contraindicated in:

Patients with known hypersensitivity

Patients with known hypersensitivity to levocetirizine or any of the ingredients of XYZAL, or to cetirizine. Observed reactions range from urticaria to anaphylaxis [see ADVERSE REACTIONS].

Patients with end-stage renal disease

Patients with end-stage renal disease (CLCR < 10 mL/min) and patients undergoing hemodialysis

Pediatric patients with impaired renal function

Children 6 months to 11 years of age with impaired renal function

Last reviewed on RxList: 11/22/2013
This monograph has been modified to include the generic and brand name in many instances.

Overdosage
Contraindications
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