Yasmin (Drospirenone and Ethinyl Estradiol) Drug Information: Overdosage and Contraindications

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May 27, 2012

Yasmin

Information on Birth Control Pills »

What are birth control pills and how do they work?

Birth control pills are also known as oral contraceptives (OCs) or, simply, “the pill.” They offer protection against pregnancy by blocking the union of sperm and egg, thereby preventing conception.

Oral contraceptives or birth control pills contain synthetic female hormones. They work largely by preventing the release of an egg from an ovary, or ovulation. If no egg is released, there can be no pregnancy.

Stopping ovulation is not the only way birth control pills can work. The progestin or synthetic progesterone in birth control pills also changes the physical and chemical environment of the female reproductive tract, making it hostile for sperm.

What are the different types of birth control pills?

The active ingredients in birth control pills are synthetic versions of the female hormones estrogen and progesterone. Combination oral contraceptives are birth control...

Read the Information on Birth Control Pills article »

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Yasmin

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OVERDOSE

There have been no reports of serious ill effects from overdose, including ingestion by children. Overdosage may cause withdrawal bleeding in females and nausea.

DRSP is a spironolactone analogue which has antimineralocorticoid properties. Serum concentration of potassium and sodium, and evidence of metabolic acidosis, should be monitored in cases of overdose.

CONTRAINDICATIONS

Do not prescribe Yasmin to women who are known to have the following:

Renal impairment
Adrenal insufficiency
A high risk of arterial or venous thrombotic diseases. Examples include women who are known to:
- Smoke, if over age 35 [see BOXED WARNINGS and WARNINGS AND PRECAUTIONS]
- Have deep vein thrombosis or pulmonary embolism, now or in the past [see WARNINGS AND PRECAUTIONS]
- Have cerebrovascular disease [see WARNINGS AND PRECAUTIONS]
- Have coronary artery disease [see WARNINGS AND PRECAUTIONS]
- Have thrombogenic valvular or thrombogenic rhythm diseases of the heart (for example, subacute bacterial endocarditis with valvular disease, or atrial fibrillation) [see WARNINGS AND PRECAUTIONS]
- Have inherited or acquired hypercoagulopathies [see WARNINGS AND PRECAUTIONS]
- Have uncontrolled hypertension [see WARNINGS AND PRECAUTIONS]
- Have diabetes mellitus with vascular disease [see WARNINGS AND PRECAUTIONS]
- Have headaches with focal neurological symptoms or have migraine headaches with or without aura if over age 35 [see WARNINGS AND PRECAUTIONS]
Undiagnosed abnormal uterine bleeding [see WARNINGS AND PRECAUTIONS]
Breast cancer or other estrogen- or progestin-sensitive cancer, now or in the past [see WARNINGS AND PRECAUTIONS]
Liver tumor (benign or malignant) or liver disease [see WARNINGS AND PRECAUTIONS and Use In Specific Populations]
Pregnancy, because there is no reason to use COCs during pregnancy [see WARNINGS AND PRECAUTIONS and Use In Specific Populations]