April 29, 2017
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Yellow Fever Vaccine

"Jan. 29, 2015 -- As a measles outbreak linked to Disneyland continues to spread, a backlash against parents who refuse or delay vaccination for their children has risen to a fever pitch.

More and more pediatricians say they are "fir"...





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YF-VAX is contraindicated in anyone with a history of acute hypersensitivity reaction to any component of the vaccine. (See DESCRIPTION section.) Because the yellow fever virus used in the production of this vaccine is propagated in chicken embryos, do not administer YF-VAX to anyone with a history of acute hypersensitivity to eggs or egg products due to a risk of anaphylaxis. Less severe or localized manifestations of allergy to eggs or to feathers are not contraindications to vaccine administration and do not usually warrant vaccine skin testing (see PRECAUTIONS section, Testing for Hypersensitivity Reactions subsection). Generally, persons who are able to eat eggs or egg products may receive the vaccine.(14) (15)

Individuals Less Than 9 Months Of Age

Vaccination with YF-VAX is contraindicated in infants less than 9 months of age due to an increased risk of encephalitis.

Vaccination with YF-VAX is also contraindicated in lactating women who are providing breastmilk to infants less than 9 months of age due to the potential for transmission of vaccine virus in breastmilk. (see PRECAUTIONS section, Nursing Mothers subsection).

Immunosuppressed Individuals

Vaccination with YF-VAX, a live virus vaccine, is contraindicated in individuals with severe immunosuppression, including for example, those with acquired immunodeficiency syndrome, leukemia, lymphoma, thymic disease, generalized malignancy, and patients who are undergoing drug therapy (e.g., systemic corticosteroids, alkylating drugs, antimetabolites or other immunomodulatory drugs) or radiation therapy. Thymic disorders associated with abnormal immune cell function (e.g., myasthenia gravis, thymoma) may be an independent risk factor for the development of yellow fever vaccine-associated viscerotropic disease, (see WARNINGS section). (16)

Do not administer YF-VAX to individuals with severe immunosuppression.

Family members of immunosuppressed persons, who themselves have no contraindications, may receive YF-VAX. (14)(17)


14 Recommendations of the Advisory Committee on Immunization Practices (ACIP). Yellow Fever Vaccine. MMWR 2010;59(RR-7):1-32.

15 Centers for Disease Control and Prevention. General Recommendations on Immunization. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 2011;60(No. RR2):(1-64).

16 Sanofi Pasteur Inc. Data on File - 080601;120104.

17 Centers for Disease Control and Prevention. CDC Health Information for International Travel 2016. New York: Oxford University Press 2016;3:346-60.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 11/3/2016


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