Yohimbe

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Are there any interactions with medications?



Medications for depression (MAOIs)
Interaction Rating: Major Do not take this combination.

Yohimbe contains a chemical that affects the body. This chemical is called yohimbine. Yohimbine might affect the body in some of the same ways as some medications for depression called MAOIs. Taking yohimbe along with MAOIs might increase the effects and side effects of yohimbe and MAOIs.

Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.



Clonidine (Catapres)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Clonidine (Catapres) is used to decrease blood pressure. Yohimbe might increase blood pressure. Taking yohimbe along with clonidine (Catapres) might decrease the effectiveness of clonidine (Catapres).



Guanabenz (Wytensin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Yohimbe contains a chemical called yohimbine. Yohimbine can decrease the effectiveness of guanabenz (Wytensin).



Medications for depression (Tricyclic antidepressants)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Yohimbe can affect the heart. Some medications used for depression called tricyclic antidepressants can also affect the heart. Taking yohimbe along with these medications used for depression might cause heart problems. Don't take yohimbe if you are taking these medications for depression.

Some of these tricyclic antidepressants medications used for depression include amitriptyline (Elavil), imipramine (Tofranil), and others.



Medications for high blood pressure (Antihypertensive drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Yohimbe seems to increase blood pressure. Taking yohimbe along with some medications for high blood pressure might decrease the effectiveness of medications for high blood pressure.

Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.



Naloxone (Narcan)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Yohimbe contains a chemical that can affect the brain. This chemical is called yohimbine. Naloxone (Narcan) also affects the brain. Taking naloxone (Narcan) along with yohimbine might increase the chance of side effects such as anxiety, nervousness, trembling, and hot flashes.



Phenothiazines
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Yohimbe contains a chemical called yohimbine. Some medications called phenothiazines have some similar effects to yohimbine. Taking yohimbe along with phenothiazines might increase the effects and side effects of yohimbine.

Some phenothiazines include chlorpromazine (Thorazine), fluphenazine (Prolixin), trifluoperazine (Stelazine), thioridazine (Mellaril), and others.



Stimulant drugs
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Yohimbe might also speed up the nervous system. Taking yohimbe along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with yohimbe.

Some stimulant drugs include diethylpropion (Tenuate), epinephrine, phentermine (Ionamin), pseudoephedrine (Sudafed), and many others.

Dosing considerations for Yohimbe.

The following doses have been studied in scientific research:

BY MOUTH:
  • For problems with sexual performance: 15-30 mg daily of yohimbine, the active ingredient in yohimbe. Doses of up to 100 mg of yohimbine daily have been used. However, significant side effects, some quite dangerous (including the possibility of death), would be expected with such a high dose.

Therapeutic Research Faculty copyright

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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