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(aspirin and omeprazole) Tablets


The active ingredients of YOSPRALA are aspirin which is an antiplatelet agent and omeprazole which is a PPI.

YOSPRALA (aspirin and omeprazole) is an oval, blue-green, multi-layer film-coated, delayed release tablet consists of an enteric coated delayed-release aspirin core surrounded by an immediate-release omeprazole layer for oral administration. Each delayed-release tablet contains either 81 mg aspirin and 40 mg omeprazole printed with 81/40, or 325 mg aspirin and 40 mg omeprazole printed with 325/40.

The excipients used in the formulation of YOSPRALA are all inactive and United States Pharmacopeia/National Formulary (USP/NF) defined. The inactive ingredients in YOSPRALA include: microcrystalline cellulose, corn starch, pre-gelatinized starch, colloidal silicon dioxide, stearic acid, methacrylic acid copolymer dispersion, triethyl citrate, glyceryl monostearate, polysorbate 80, titanium dioxide, hydroxypropyl methycellulose, polyethylene glycol, polydextrose, triacetin, yellow iron oxide, FD&C Blue #2, talc, sodium phosphate dibasic anhydrous, carnauba wax and povidone.

Aspirin is acetylsalicylic acid and is chemically known as benzoic acid, 2-(acetyloxy). Aspirin is an odorless white needle-like crystalline or powdery substance. When exposed to moisture, aspirin hydrolyzes into salicylic and acetic acids and gives off a vinegary odor. It is highly lipid soluble and slightly soluble in water. Aspirin irreversibly inhibits platelet COX-1.

Omeprazole is a white to off-white crystalline powder which melts with decomposition at about 155 °C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of omeprazole is a function of pH; it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions.

Omeprazole is a substituted benzimidazole, 5-methoxy-2-[[(4-methoxy-3, 5-dimethyl-2- pyridinyl) methyl] sulfinyl]-1H- benzimidazole, a compound that inhibits gastric acid secretion.

Structural Formula


Aspirin - Structural Formula Illustration


Omeprazole - Structural Formula Illustration

Molecular Formula

The empirical formula of aspirin is C9H8O4 .

The empirical formula of omeprazole is C17H19N3O3S.

Molecular Weight

The molecular weight of aspirin is 180.16.

The molecular weight of omeprazole is 345.4.

Last reviewed on RxList: 10/21/2016
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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