Zagam (Sparfloxacin) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 21, 2012

Zagam

Pneumonia »

Pneumonia facts

Pneumonia is a lung infection that can be caused by different types of microorganisms, including bacteria, viruses, and fungi.
Symptoms of pneumonia include cough with sputum production, fever, and sharp chest pain on inspiration (breathing in).
Pneumonia is suspected when a doctor hears abnormal sounds in the chest, and the diagnosis is confirmed by a chest X-ray.
Bacteria causing pneumonia can be identified by sputum culture.
A pleural effusion is a fluid collection around the inflamed lung.
Bacterial and fungal (but not viral) pneumonia can be treated with antibiotics.

What is pneumonia?

Pneumonia is an infection of one or both lungs which is usually caused by bacteria, viruses, or fungi. Prior to the discovery of antibiotics, one-third of all people who developed pneumonia subsequently died fro...

Read the Pneumonia article »

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Zagam

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Zagam®
(sparfloxacin)

DRUG DESCRIPTION

Zagam® (sparfloxacin) Tablets contain sparfloxacin, a synthetic broad-spectrum antimicrobial agent for oral administration. Sparfloxacin, an aminodifluoroquinolone, is 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. Its empirical formula is C₁₉H₂₂F₂N₄O₃ and it has the following chemical structure:

Zagam® (sparfloxacin) Structural Formula Illustration

Sparfloxacin has a molecular weight of 392.41. It occurs as a yellow crystalline powder. It is sparingly soluble in glacial acetic acid or chloroform, very slightly soluble in ethanol (95%), and practically insoluble in water and ether. It dissolves in dilute acetic acid or 0.1 N sodium hydroxide.

Zagam (sparfloxacin) is available as a 200-mg round, white film-coated tablet. Each 200-mg tablet contains the following inactive ingredients: microcrystalline cellulose NF, corn starch NF, L-hydroxypropylcellulose NF, magnesium stearate NF, and colloidal silicone dioxide NF. The film coating contains: methylhydroxypropylcellulose USP, polyethylene glycol 6000, and titanium dioxide USP.

What are the possible side effects of sparfloxacin (Zagam, Zagam Respipac)?

If you experience any of the following serious side effects, stop taking sparfloxacin and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
irregular heartbeats;
chest pain, chest discomfort, shortness of breath, or swelling of your legs or feet;
severe dizziness;
seizures;
confusion or hallucinations;
liver damage (yellowing of the skin or eyes,...

Read All Potential Side Effects and See Pictures of Zagam »

Last reviewed on RxList: 4/7/2009
This monograph has been modified to include the generic and brand name in many instances.