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This drug should not be used with the following medications because very serious interactions may occur: ciprofloxacin, fluvoxamine.

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting tizanidine.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: antiarrhythmics (e.g., amiodarone, mexiletine, propafenone, verapamil), birth control pills, blood pressure drugs (e.g., ACE inhibitors such as lisinopril, beta blockers such as propranolol, clonidine, methyldopa, guanabenz, guanfacine), cimetidine, drugs affecting liver enzymes that remove tizanidine from your body (e.g., zileuton, ticlopidine, acyclovir, fluoroquinolone antibiotics such as norfloxacin), "water pills" (e.g., furosemide, thiazides).

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-anxiety drugs (e.g., diazepam), anti-seizure drugs (e.g., carbamazepine), medicine for sleep (e.g., sedatives), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline), tranquilizers. Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products.

Do not use non-prescription medications that contain cimetidine for relief of upset stomach or heartburn.

Do not start or stop any medicine without doctor or pharmacist approval.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include severe drowsiness, fainting, trouble breathing, and unconsciousness.

NOTES: Laboratory and/or medical tests (e.g., blood pressure, liver function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Do not share this medication with others.

MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store away from light and moisture at room temperature at 77 degrees F (25 degrees C). Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep this and all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised May 2010 Copyright(c) 2010 First DataBank, Inc.