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There has been virtually no experience with overdosage with ZANTAC Injection (ranitidine hydrochloride injection) and limited experience with oral doses of ranitidine. Reported acute ingestions of up to 18 g orally have been associated with transient adverse effects similar to those encountered in normal clinical experience (see ADVERSE REACTIONS). In addition, abnormalities of gait and hypotension have been reported.
When overdosage occurs, clinical monitoring and supportive therapy should be employed.
Studies in dogs receiving dosages of ZANTAC in excess of 225 mg/kg/day have shown muscular tremors, vomiting, and rapid respiration. Single oral doses of 1,000 mg/kg in mice and rats were not lethal. Intravenous LD50 values in mice and rats were 77 and 83 mg/kg, respectively.
ZANTAC Injection (ranitidine hydrochloride injection) and ZANTAC Injection (ranitidine hydrochloride injection) Premixed are contraindicated for patients known to have hypersensitivity to the drug.
Last reviewed on RxList: 3/31/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Zantac Injection Information
- Zantac Injection Drug Interactions Center: ranitidine hcl inj
- Zantac Injection Side Effects Center
- Zantac Injection FDA Approved Prescribing Information including Dosage
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