Zantac Injection (Ranitidine Hydrochloride Injection) Drug Information: Overdosage and Contraindications

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May 27, 2012

Zantac Injection

Gastroesophageal Reflux Disease (GERD) »

GERD Facts

GERD is a condition in which the acidified liquid content of the stomach up into the esophagus.
The causes of GERD include an abnormal lower esophageal sphincter, hiatal hernia, abnormal esophageal contractions, and slow emptying of the stomach.
GERD may damage the lining of the esophagus, thereby causing inflammation (esophagitis), although usually it does not.
The symptoms of uncomplicated GERD are heartburn, regurgitation, and nausea.
Complications of GERD include ulcers and strictures of the esophagus, Barrett's esophagus, cough and asthma, throat and laryngeal inflammation, inflammation and infection of the lungs, and collection of fluid in the sinuses and middle ear.
Barrett's esophagus is a pre-cancerous condition that requires periodic endoscopic surveillance for the development of cancer.
GERD may be diagnosed or evaluate...

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Zantac Injection

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OVERDOSE

There has been virtually no experience with overdosage with ZANTAC Injection (ranitidine hydrochloride injection) and limited experience with oral doses of ranitidine. Reported acute ingestions of up to 18 g orally have been associated with transient adverse effects similar to those encountered in normal clinical experience (see ADVERSE REACTIONS). In addition, abnormalities of gait and hypotension have been reported.

When overdosage occurs, clinical monitoring and supportive therapy should be employed.

Studies in dogs receiving dosages of ZANTAC in excess of 225 mg/kg/day have shown muscular tremors, vomiting, and rapid respiration. Single oral doses of 1,000 mg/kg in mice and rats were not lethal. Intravenous LD50 values in mice and rats were 77 and 83 mg/kg, respectively.

CONTRAINDICATIONS

ZANTAC Injection (ranitidine hydrochloride injection) and ZANTAC Injection (ranitidine hydrochloride injection) Premixed are contraindicated for patients known to have hypersensitivity to the drug.

Last reviewed on RxList: 3/31/2009
This monograph has been modified to include the generic and brand name in many instances.