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Acute overdoses may produce nausea, vomiting, and CNS depression including coma with respiratory depression. A relationship between ethosuximide toxicity and its plasma levels has not been established.
Treatment should include emesis (unless the patient is or could rapidly become obtunded, comatose, or convulsing) or gastric lavage, activated charcoal, cathartics, and general supportive measures. Hemodialysis may be useful to treat ethosuximide overdose. Forced diuresis and exchange transfusions are ineffective.
Ethosuximide should not be used in patients with a history of hypersensitivity to succinimides.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 5/21/2012
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