Zarontin Oral Solution
"A relatively new once-a-day antiepileptic drug (AED) is as effective as an older standard one given twice daily, according to a randomized trial.
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Zarontin Oral Solution
Zarontin is indicated for the control of absence (petit mal) epilepsy.
DOSAGE AND ADMINISTRATION
Zarontin is administered by the oral route. The initial dose for patients 3 to 6 years of age is one teaspoonful (250 mg) per day; for patients 6 years of age and older, 2 teaspoonfuls (500 mg) per day. The dose thereafter must be individualized according to the patient's response. Dosage should be increased by small increments. One useful method is to increase the daily dose by 250 mg every four to seven days until control is achieved with minimal side effects. Dosages exceeding 1.5 g daily, in divided doses, should be administered only under the strictest supervision of the physician. The optimal dose for most pediatric patients is 20 mg/kg/day. This dose has given average plasma levels within the accepted therapeutic range of 40 to 100 mcg/mL. Subsequent dose schedules can be based on effectiveness and plasma level determinations.
Zarontin may be administered in combination with other anticonvulsants when other forms of epilepsy coexist with absence (petit mal). The optimal dose for most pediatric patients is 20 mg/kg/day.
Zarontin is supplied as:
NDC 0071-2418-23 - 1 pint bottles. Each 5 mL of oral solution contains 250 mg ethosuximide in a raspberry flavored base.
Store at 20°-25°C (68°-77°F); [see USP Controlled Room Temperature],
Preserve in tight containers. Protect from freezing and light.
Distributed by: Parke-Davis Division of Pfizer Inc, NY, NY 10017. Revised: Sep 2013This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 1/5/2017
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