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(selegiline hydrochloride) Orally Disintegrating Tablets


ZELAPAR Orally Disintegrating Tablets contain selegiline hydrochloride, a levorotatory acetylenic derivative of phenethylamine. Selegiline hydrochloride is described chemically as: (-)-(R)-N, α- dimethyl-N-2-propynylphenethylamine hydrochloride and its structural formula is:

ZELAPAR® (selegiline hydrochloride) Structural Formula Illustration

Its empirical formula is C13H17N·HCl, representing a molecular weight of 223.75. Selegiline hydrochloride is a white to almost white crystalline powder that is freely soluble in water, chloroform, and methanol.

ZELAPAR Orally Disintegrating Tablets are available for oral administration (not to be swallowed) in a strength of 1.25 mg. Each lyophilized orally disintegrating tablet contains the following inactive ingredients: gelatin, mannitol, glycine, aspartame, citric acid, yellow iron oxide, and grapefruit flavor.

What are the possible side effects of selegiline (Eldepryl, Zelapar)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking selegiline and call your doctor at once if you have any of these serious side effects:

  • sudden and severe headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, seizure (convulsions), and sudden numbness or weakness (especially on one side of the body);
  • feeling light-headed, fainting;
  • hallucinations;
  • feeling restless,...

Read All Potential Side Effects and See Pictures of Zelapar »

What are the precautions when taking selegiline hydrochloride (Zelapar)?

Before taking selegiline, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain kind of adrenal gland tumor (pheochromocytoma), cerebrovascular disease (e.g., stroke), heart problems (e.g., congestive heart failure, heart attack), bleeding problems, peptic ulcer, history of severe/frequent headaches, diabetes, personal/family history of mental/mood disorders (e.g., schizophrenia, bipolar disorder), personal/family history of high blood pressure, kidney disease, liver disease, overactive thyroid...

Read All Potential Precautions of Zelapar »

Last reviewed on RxList: 12/28/2016
This monograph has been modified to include the generic and brand name in many instances.

Zelapar - User Reviews

Zelapar User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Zelapar sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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