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Zelapar

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Zelapar

PATIENT INFORMATION

Patients should be advised of the possible need to reduce levodopa dosage after the initiation of ZELAPAR® (selegiline hydrochloride) therapy.

Patients (or their families if the patient is incompetent) should be advised not to exceed the daily recommended dose of 2.5 mg. The risk of using higher daily doses of ZELAPAR® (selegiline hydrochloride) should be explained, and a brief description of the hypertensive/cheese reaction provided. Rare hypertensive reactions with oral selegiline at recommended doses associated with dietary influences have been reported.

Consequently, it may be useful to inform patients (or their families) about the signs and symptoms associated with MAOI induced hypertensive reactions. In particular, patients should be urged to report, immediately, any severe headache or other atypical or unusual symptoms not previously experienced.

Patients should be informed that hallucinations can occur.

There have been reports of patients experiencing intense urges to gamble, increased sexual urges, and other intense urges and the inability to control these urges while taking one or more of the medications that increase central dopaminergic tone, that are generally used for the treatment of Parkinson's disease, including Zelapar (selegiline hydrochloride) . Although it is not proven that the medications caused these events, these urges were reported to have stopped in some cases when the dose was reduced or the medication was stopped. Prescribers should ask patients about the development of new or increased gambling urges, sexual urges or other urges while being treated with Zelapar (selegiline hydrochloride) . Patients should inform their physician if they experience new or increased gambling urges, increased sexual urges or other intense urges while taking Zelapar (selegiline hydrochloride) . Physicians should consider dose reduction or stopping the medication if a patient develops such urges while taking Zelapar (selegiline hydrochloride) .

Patients should be instructed not to remove the blister from the outer pouch until just prior to dosing. The blister pack should then be peeled open with dry hands and the orally disintegrating tablet placed on the tongue, where it will disintegrate. Patients should also avoid drinking liquids or eating food five minutes before and after taking ZELAPAR® (selegiline hydrochloride) .

Last reviewed on RxList: 2/19/2009
This monograph has been modified to include the generic and brand name in many instances.

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