April 29, 2017
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Zemplar Capsules

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Zemplar Capsules

(paricalcitol) Capsules


Paricalcitol, USP, the active ingredient in ZEMPLAR capsules, is a synthetically manufactured, metabolically active vitamin D analog of calcitriol with modifications to the side chain (D2) and the A (19-nor) ring. ZEMPLAR is available as soft gelatin capsules for oral administration containing 1 microgram or 2 micrograms of paricalcitol. Each capsule also contains medium chain triglycerides, alcohol, and butylated hydroxytoluene. The medium chain triglycerides are fractionated from coconut oil or palm kernel oil. The capsule shell is composed of gelatin, glycerin, titanium dioxide, iron oxide red (2 microgram capsules only), iron oxide yellow (2 microgram capsules only), iron oxide black (1 microgram capsules only), and water.

Paricalcitol is a white, crystalline powder with the empirical formula of C27H44O3, which corresponds to a molecular weight of 416.64. Paricalcitol is chemically designated as 19-nor1α,3β,25-trihydroxy-9,10-secoergosta-5(Z),7(E),22(E)-triene and has the following structural formula:

ZEMPLAR (paricalcitol)  Structural Formula Illustration

What are the possible side effects of paricalcitol (Zemplar)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking paricalcitol and call your doctor at once if you have a serious side effect such as:

  • fever, chills, body aches, flu symptoms;
  • chest pain, feeling short of breath;
  • feeling like you might pass out;
  • swelling, rapid weight gain;
  • pain or burning when you urinate;
  • dry mouth, drowsiness, increased urination, fast heart rate, feeling light-headed, fainting, or...

Read All Potential Side Effects and See Pictures of Zemplar Capsules »

What are the precautions when taking paricalcitol (Zemplar Capsules)?

Before taking paricalcitol, tell your doctor or pharmacist if you are allergic to it; or to other vitamin D products; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: high levels of calcium (hypercalcemia), high levels of vitamin D (hypervitaminosis D), heart disease (e.g., irregular heartbeat, coronary artery disease), seizures.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when...

Read All Potential Precautions of Zemplar Capsules »

Last reviewed on RxList: 1/23/2017
This monograph has been modified to include the generic and brand name in many instances.

Zemplar Capsules - User Reviews

Zemplar Capsules User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Zemplar Capsules sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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