Zemplar Capsules (Paricalcitol) Drug Information: Overdosage and Contraindications

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May 27, 2012

Zemplar Capsules

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OVERDOSE

Excessive administration of Zemplar Capsules (paricalcitol) can cause hypercalcemia, hypercalciuria, and hyperphosphatemia, and over suppression of PTH (see WARNINGS).

Treatment of Overdosage

The treatment of acute overdosage of Zemplar Capsules (paricalcitol) should consist of general supportive measures. If drug ingestion is discovered within a relatively short time, induction of emesis or gastric lavage may be of benefit in preventing further absorption. If the drug has passed through the stomach, the administration of mineral oil may promote its fecal elimination. Serial serum electrolyte determinations (especially calcium), rate of urinary calcium excretion, and assessment of electrocardiographic abnormalities due to hypercalcemia should be obtained. Such monitoring is critical in patients receiving digitalis. Discontinuation of supplemental calcium and institution of a low-calcium diet are also indicated in accidental overdosage. Due to the relatively short duration of the pharmacological action of paricalcitol, further measures are probably unnecessary. If persistent and markedly elevated serum calcium levels occur, there are a variety of therapeutic alternatives that may be considered depending on the patient's underlying condition. These include the use of drugs such as phosphates and corticosteroids, as well as measures to induce an appropriate forced diuresis.

CONTRAINDICATIONS

Zemplar Capsules (paricalcitol) should not be given to patients with evidence of vitamin D toxicity, hypercalcemia, or hypersensitivity to any ingredient in this product (see WARNINGS).

Last reviewed on RxList: 7/20/2009
This monograph has been modified to include the generic and brand name in many instances.